2-氨基-5-硝基苯甲酸甲酯合成路线 （共 19 条）
反应条件
1: With sulfuric acid Reflux; 2: With sodium carbonate in methanol; water T=20°C;
参考文献
BIOLIPOX AB; PELCMAN, Benjamin; ALMEIDA, Maria; KATKEVICS, Martins; NILSSON, Peter; SCHAAL, Wesley; OLOFSSON, Kristofer
Patent: WO2010/29300 A1, 2010 ;
Location in patent: Page/Page column 74 ;
WO 2010/029300 A1
反应条件
sulfuric acid T=80°C; 72 h; Inert atmosphere;
参考文献
Lo Conte, Mauro; Carroll, Kate S.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 26 p. 6502 - 6505
参考文献
SmithKline Beecham Corporation
Patent: US5693636 A1, 1997 ;
反应条件
1: 5-nitro-isoindole-1,3-dione With sodium hydroxide; Ca(OCl)2 in 1,4-dioxane T=0 - 100°C; Hofmann rearrangement; 2.5 h; 2: methanol With sulfuric acid Esterification; Heating;
参考文献
Kreimeyer, Annett; Laube, Bodo; Sturgess, Mike; Goeldner, Maurice; Foucaud, Bernard
Journal of Medicinal Chemistry, 1999 , vol. 42, # 21 p. 4394 - 4404
反应条件
potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
N,N-tetramethylene-thiocarbamoyl-sulphenamide in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
sodium hydroxide 0.25 h; Heating;
参考文献
Das, Jagattaran; Sitaram Kumar; Subrahmanyam; Sastry; Prasad Narasimhulu; Laxman Rao; Kannan; Roshaiah; Awasthi, Riti; Patil, Santosh N.; Sarnaik; Rao Mamidi; Selvakumar; Iqbal, Javed
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 8032 - 8042
参考文献
Bogert; Scatchard
Journal of the American Chemical Society, 1919 , vol. 41, p. 2061
反应条件
1: acetic acid; nitric acid / acetic anhydride / 0.33 h / 18 - 20 °C 2: sulfuric acid / 0.5 h / 0 °C View Scheme
参考文献
Porcs-Makkay, Marta; Mezei, Tibor; Simig, Gyula
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 490 - 493
