5-甲基-3,4-二苯基-异噁唑合成路线 （共 19 条）
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78 - 20°C; 4 h; 2: With sulfuric acid in dichloromethane 3 h; Heating / reflux;
参考文献
CJ CORP.
Patent: WO2004/35553 A1, 2004 ;
Location in patent: Page 22-23 ;
反应条件
trifluoroacetic acid in ethyl acetate T=68 - 70°C; 0.216667 h; Product distribution / selectivity;
参考文献
PHARMACIA CORPORATION?
Patent: WO2005/123701 A1, 2005 ;
Location in patent: Page/Page column 29-30; 34-35 ;
反应条件
hydrogenchloride in water T=40 - 102°C; 2 - 21.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
Dr. Reddy's Laboratories Ltd.; Dr. Reddy's Laboratories, Inc.
Patent: EP1550658 A1, 2005 ;
Location in patent: Page/Page column 6; 8 ;
反应条件
1: in benzene T=5 - 35°C; 1 h; 2: With hydrogenchloride in water T=25 - 35°C; 5 h; Heating / reflux; Product distribution / selectivity;
参考文献
Dr. Reddy's Laboratories Ltd.; Dr. Reddy's Laboratories, Inc.
Patent: EP1550658 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
反应条件
silver nitrate in ethanol; water heating on a steam bath;
参考文献
Hansen, John F.; Kim, Yong In; McCrotty, Stephen E.; Strong, Scott A.; Zimmer, Douglas E.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 475 - 479
反应条件
1: With triethylamine in dichloromethane T=25 - 35°C; 3 h; 2: With hydrogenchloride in water T=100°C; 3 h;
参考文献
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar
Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
反应条件
acetic acid 5 h; Heating;
参考文献
Pennings, Marcel L.M.; Reinhoudt, David N.; Harkema, Sybolt; Hummel, Gerrit J. van
Journal of Organic Chemistry, 1982 , vol. 47, # 23 p. 4419 - 4425
反应条件
1: 76 percent / NaOH / H2O; methanol / 1 h / Heating 2: 40 percent / glacial acetic acid / 5 h / Heating View Scheme
参考文献
Pennings, Marcel L.M.; Reinhoudt, David N.; Harkema, Sybolt; Hummel, Gerrit J. van
Journal of Organic Chemistry, 1982 , vol. 47, # 23 p. 4419 - 4425
反应条件
1: 70 percent / N-bromosuccinimide / benzene / 20 - 25 °C 2: 92 percent / silver nitrate / ethanol; H2O / heating on a steam bath View Scheme
参考文献
Hansen, John F.; Kim, Yong In; McCrotty, Stephen E.; Strong, Scott A.; Zimmer, Douglas E.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 475 - 479
反应条件
1: cyclohexane / 8 h / 70 - 80 °C / Large scale reaction 2: triethylamine / dichloromethane / 5 - 35 °C / Large scale reaction 3: hydrogenchloride / water / 98 - 102 °C / Large scale reaction View Scheme
参考文献
Reddy, Anumula Raghupathi; Goverdhan, Gilla; Sampath, Aalla; Mukkanti, Khagga; Reddy, Padi Pratap; Bandichhor, Rakeshwar
Synthetic Communications, 2012 , vol. 42, # 5 p. 639 - 649
