4,4',4''-三氟三苯甲醇合成路线 （共 8 条）
反应条件
potassium hydroxide; oxygen in ethylene glycol dimethyl ether T=70°C; 3 h;
参考文献
Artamkina, G. A.; Grinfel'd, A. A.; Beletskaya, I. P.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983 , vol. 32, # 2 p. 345 - 352
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983 , # 2 p. 383 - 391
反应条件
in tetrahydrofuran 2 h; Heating;
参考文献
Dhar; Borden; Tyagarajan; Smith; Branchek; Weinshank; Gluchowski
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2334 - 2342
反应条件
in tetrahydrofuran T=-80 - 20°C; Inert atmosphere;
参考文献
Bottalico, Daniela; Fiandanese, Vito; Marchese, Giuseppe; Punzi, Angela
Synthesis, 2009 , # 14 art. no. T04309SS, p. 2316 - 2318
参考文献
Marvel et al.
Journal of the American Chemical Society, 1944 , vol. 66, p. 914,917
Full Text Show Details
Bacon; Gardner
Journal of Organic Chemistry, 1938 , vol. 3, p. 281,283
反应条件
1: methanol / Einleiten von Chlorwasserstoff 2: diethyl ether View Scheme
参考文献
Bacon; Gardner
Journal of Organic Chemistry, 1938 , vol. 3, p. 281,283
反应条件
magnesium 1.) terbutyl methyl ether, THF, iodine, dichloroethane, reflux, 2.) reflux, 2.5 h; Multistep reaction;
参考文献
Bartroli; Alguero; Boncompte; Forn
Arzneimittel-Forschung/Drug Research, 1992 , vol. 42, # 6 p. 832 - 835
反应条件
formic acid
5 h; Heating;
参考文献
Andrews, Adrian F.; Mackie, Raymond K.; Walton, John C.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 96 - 102
反应条件
hydrogenchloride; Petroleum ether
参考文献
McNaughton-Smith, Grant A.; Burns, J. Ford; Stocker, Jonathan W.; Rigdon, Gregory C.; Creech, Christopher; Arlington, Susan; Shelton, Tara; De Franceschi, Lucia
Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 976 - 982
