2-氮杂丁烷-1,4-二羧酸二乙酯合成路线 （共 17 条）
参考文献
PFIZER INC.
Patent: WO2008/96218 A1, 2008 ;
Location in patent: Page/Page column 57-58 ;
反应条件
sodium hydroxide in dichloromethane T=20°C;
参考文献
Tran, Joe A.; Tucci, Fabio C.; Arellano, Melissa; Jiang, Wanlong; Chen, Caroline W.; Marinkovic, Dragan; Fleck, Beth A.; Wen, Jenny; Foster, Alan C.; Chen, Chen
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 6 p. 1931 - 1938
反应条件
1: 90 percent / aq. NaOH / CHCl3 / 11 h / 0 - 20 °C 2: 37 percent / t-BuOK / toluene / 1.42 h / 0 °C View Scheme
参考文献
Calugi, Chiara; Trabocchi, Andrea; Lalli, Claudia; Guarna, Antonio
European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 96 - 107
反应条件
Yield given. Multistep reaction;
参考文献
Ohsawa, Tatsushi; Ihara, Masataka; Fukumoto, Keiichiro; Kametani, Tetsuji
Journal of Organic Chemistry, 1983 , vol. 48, # 21 p. 3644 - 3648
反应条件
triethylamine in ethanol
T=20°C;
参考文献
Williams, Robert M.; Cao, Jianhua; Tsujishima, Hidekazu; Cox, Rhona J.
Journal of the American Chemical Society, 2003 , vol. 125, # 40 p. 12172 - 12178
反应条件
sodium hydroxide in water
T=0 - 20°C;
参考文献
ALNYLAM PHARMACEUTICALS, INC.
Patent: WO2007/56331 A2, 2007 ;
Location in patent: Page/Page column 48-49 ;
反应条件
triethylamine in ethanol
T=20°C; 72 h;
参考文献
PFIZER INC.
Patent: WO2008/96218 A1, 2008 ;
Location in patent: Page/Page column 57 ;
反应条件
1: glycine ethyl ester hydrochloric acid With potassium carbonate in N,N-dimethyl acetamide
T=20°C; 0.5 h;
2: ethyl acrylate in N,N-dimethyl-formamide
T=80°C; 8 h;
参考文献
Bradbury, Barton J.; Deshpande, Milind; Pucci, Michael J.; Wang, Qiuping; Wiles, Jason Allan; Song, Yongsheng; Hashimoto, Akihiro; Lucien, Edlaine
Patent: US2006/100215 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogenchloride in ethanol
参考文献
Ciba-Geigy Corporation
Patent: US4906621 A1, 1990 ;
反应条件
in benzene
T=60°C; Condensation; 5 h;
参考文献
St-Denis; Tak Hang Chan
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 776 - 783
