1-叔丁氧羰基-(4R)-羟基-2-脯氨酸乙脂合成路线 （共 17 条）
反应条件
in water; N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
Ojima, Iwao; Kogure, Tetsuo; Yoda, Noriko
Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4728 - 4739
反应条件
N,N-dicyclohexylamine in ethyl acetate; N,N-dimethyl-formamide
参考文献
Kitamatsu, Mizuki; Kashiwagi, Tomoko; Matsuzaki, Rino; Sisido, Masahiko
Chemistry Letters, 2006 , vol. 35, # 3 p. 300 - 301
反应条件
1: ethanol; (2S,4R)-2-carboxy-4-hydroxypyrrolidine With thionyl chloride
16 h; Heating;
2: di-tert-butyl dicarbonate With triethylamine in dichloromethane
17 h;
参考文献
Taylor, Carol M.; Hardre, Renaud; Edwards, Patrick J. B.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1306 - 1315
反应条件
1: 95 percent / NaHCO3 / dioxane; H2O
2: 94 percent / DCHA / ethyl acetate; dimethylformamide
View Scheme
参考文献
Kitamatsu, Mizuki; Kashiwagi, Tomoko; Matsuzaki, Rino; Sisido, Masahiko
Chemistry Letters, 2006 , vol. 35, # 3 p. 300 - 301
反应条件
triethylamine in dichloromethane
参考文献
Merino, Pedro; Revuelta, Julia; Tejero, Tomas; Chiacchio, Ugo; Rescifina, Antonio; Piperno, Anna; Romeo, Giovanni
Tetrahedron Asymmetry, 2002 , vol. 13, # 2 p. 167 - 172
反应条件
in N,N-dimethyl-formamide
T=20°C; 39 h;
参考文献
Kitamatsu, Mizuki; Shigeyasu, Masanori; Okada, Tomoyuki; Sisido, Masahiko
Chemical Communications, 2004 , # 10 p. 1208 - 1209
反应条件
1: 95 percent / NaHCO3 / dioxane; H2O
2: 94 percent / DCHA / ethyl acetate; dimethylformamide
View Scheme
参考文献
Kitamatsu, Mizuki; Kashiwagi, Tomoko; Matsuzaki, Rino; Sisido, Masahiko
Chemistry Letters, 2006 , vol. 35, # 3 p. 300 - 301
