3-氧代-4-苯基丁酸甲酯合成路线 （共 29 条）
反应条件
bis(cyclopentadienyl)titanium dichloride; iso-propylmagnesium bromide in tetrahydrofuran; diethyl ether 4 h; Ambient temperature;
参考文献
Synthetic Communications, , vol. 29, # 2 p. 243 - 247
反应条件
sodium in methanol 5 h; Heating;
参考文献
Mai, Antonello; Artico, Marino; Sbardella, Gianluca; Massa, Silvio; Loi, Anna Giulia; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3258 - 3263
反应条件
1: 85 percent / methanesulfonyl azide, triethylamine / acetonitrile / 3 h / Ambient temperature 2: 76 percent / Rh2(OAc)4 / CH2Cl2 View Scheme
参考文献
Taber,D.F.; Ruckle,R.E.
Journal of the American Chemical Society, 1986 , vol. 108, p. 7686
反应条件
1: sodium hydroxide, water / ethanol 2: pyridine View Scheme
参考文献
Grayson, David H.; Tuite, Mathew R. J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 2137 - 2142
反应条件
1: 70 percent / NaH / benzene; dimethylformamide / 1) 24h, 45-50 deg C 2) 24h, 80 deg C
2: 93 percent / NaOH / methanol; H2O / 3 h / Heating
3: 92 percent / NaBH4 / ethanol; H2O / 15 h / Ambient temperature
View Scheme
参考文献
Shankaran, K.; Talekar, D. G.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 408 - 410
反应条件
1: 78 percent / hydrazine hydrate / ethanol / 3 h / Ambient temperature
2: 85 percent / thallium(III) nitrate / 1.) room temperature, 20 min, 2.) reflux, 20 min
View Scheme
参考文献
Kato; Saino; Nishizawa; Takita; Umezawa
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 7, p. 1618 - 1621
反应条件
1: 60 percent / NaH / benzene; dimethylformamide
2: 91 percent / NaOH / methanol; H2O / Heating
3: 92 percent / NaBH4 / ethanol; H2O / 15 h / Ambient temperature
View Scheme
参考文献
Shankaran, K.; Talekar, D. G.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 408 - 410
反应条件
1: 70 percent / NaH / benzene; dimethylformamide / 1) 24h, 45-50 deg C 2) 24h, 80 deg C
2: 93 percent / NaOH / methanol; H2O / 3 h / Heating
View Scheme
参考文献
Shankaran, K.; Talekar, D. G.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 5 p. 408 - 410
反应条件
1: (i) NaOEt, EtOH, (ii) Ac2O, H2SO4
2: Zn, AcOH / Heating
View Scheme
参考文献
Ried,W.; Wagner,R.
Justus Liebigs Annalen der Chemie, 1970 , vol. 741, p. 181 - 188
