(S)-2-苯基-1-丙醇合成路线 （共 88 条）
反应条件
potassium tert-butylate; hydrogen; RuCl2[(S)-DMM-SDP](R,R)-DACH in isopropyl alcohol T=20°C; P=375030 Torr; 8 h; Title compound not separated from byproducts;
参考文献
Giacomini, Daria; Galletti, Paola; Quintavalla, Arianna; Gucciardo, Gabriele; Paradisi, Francesca
Chemical Communications, 2007 , # 39 p. 4038 - 4040
反应条件
1: With trimethylaluminum in toluene T=-60 - 20°C; 5.83333 h; Cooling with acetone-dry ice; 2: With sodium sulfate in tetrahydrofuran; water T=20°C; 1.5 h;
参考文献
Aikins, James Abraham; Fray, Andrew Hendley; Miller, William David; Ornstein, Paul Leslie; Zarrinmayeh, Hamideh; Zimmerman, Dennis Michael
Patent: US2003/233015 A1, 2003 ;
Location in patent: Page 13 ;
反应条件
1: in toluene T=-60 - 20°C; 5.83333 h; Under nitrogenCooling with acetone-dry ice; 2: With water in tetrahydrofuran; toluene 0.5 h;
参考文献
Arnold, Macklin Brian; Bleisch, Thomas John; Cuff, George William; Ornstein, Paul Leslie; Zimmerman, Dennis Michael
Patent: US2003/225163 A1, 2003 ;
Location in patent: Page 13-14 ;
反应条件
C32H12BF24(1-)*C50H42IrNO4P(1+); hydrogen in dichloromethane T=20°C; P=37503.8 Torr; 2 h; optical yield given as percent ee;
参考文献
Mazuela, Javier; Pamies, Oscar; Dieguez, Montserrat
ChemCatChem, 2013 , vol. 5, # 8 p. 2410 - 2417
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Spino; Beaulieu
Journal of the American Chemical Society, 1998 , vol. 120, # 45 p. 11832 - 11833
反应条件
1: With ozone in dichloromethane T=-78°C; Ozonolysis; 2: With sodium tetrahydroborate in methanol T=20°C; Ring cleavage; Reduction; 10 h; Further stages.;
参考文献
Spino; Beaulieu; Lafreniere
Journal of Organic Chemistry, 2000 , vol. 65, # 21 p. 7091 - 7097
反应条件
1: With ozone in methanol T=-78°C; ozonolysis; 2: With sodium tetrahydroborate in methanol T=-78 - 0°C; Further stages.;
参考文献
Takimoto, Masanori; Mori, Miwako
Journal of the American Chemical Society, 2002 , vol. 124, # 34 p. 10008 - 10009
反应条件
1: methyllithium With copper (I) cyanide in tetrahydrofuran; diethyl ether T=-84 - -20°C; Inert atmosphere; 2: With boron trifluoride diethyl etherate in tetrahydrofuran; diethyl ether T=-84°C; 0.0833333 h; 3: (S)-(-)-styrene oxide Further stages;
参考文献
Jakobsche, Charles E.; Peris, Gorka; Miller, Scott J.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 35 p. 6707 - 6711
反应条件
C32H12BF24(1-)*C52H70IrNO3PS(1+); hydrogen in dichloromethane T=20°C; P=37503.8 Torr; 2 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Coll, Mercedes; Pamies, Oscar; Dieguez, Montserrat
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 143 - 160
反应条件
sodium tetrahydroborate in methanol T=0°C; 4 h;
参考文献
Maslinska-Solich, Jolanta; Rudnicka, Irena; Jedlinski, Zbigniew J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 3034 - 3040
