1,1,1-三甲基-N-苯基哌啶合成路线 （共 76 条）
反应条件
1: HN(SiMe3)(Ph) With n-butyl-magnesium bromide in anhydrous butyl ether T=0 - 100°C; 1 h; Inert atmosphere; 2: 2-bromo-pyridine With lithium bromide; iron(II) chloride in anhydrous butyl ether T=140°C; 3 h; Inert atmosphere;
参考文献
Hatakeyama, Takuji; Imayoshi, Ryuji; Yoshimoto, Yuya; Ghorai, Sujit K.; Jin, Masayoshi; Takaya, Hikaru; Norisuye, Kazuhiro; Sohrin, Yoshiki; Nakamura, Masaharu
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20262 - 20265
反应条件
1: N-bromosuccinimide / CCl4 / 24 h / -20 °C 2: N-bromosuccinimide / CCl4 / 24 h / Ambient temperature 3: CH3OH / 0.02 h View Scheme
参考文献
Ando, Wataru; Tsumaki, Hidetoshi
Synthesis, 1982 , # 4 p. 263 - 264
反应条件
in acetonitrile 1 h; RefluxInert atmosphere;
参考文献
Naredla, Rajasekhar Reddy; Klumpp, Douglas A.
Tetrahedron Letters, 2013 , vol. 54, # 45 p. 5945 - 5947
反应条件
1: HN(SiMe3)(Ph) With n-butyl-magnesium bromide in anhydrous butyl ether T=0 - 100°C; 1 h; Inert atmosphere; 2: 4,4'-dibromo biphenyl With lithium bromide; iron(II) chloride in anhydrous butyl ether T=140°C; 24 h; Inert atmosphere;
参考文献
Hatakeyama, Takuji; Imayoshi, Ryuji; Yoshimoto, Yuya; Ghorai, Sujit K.; Jin, Masayoshi; Takaya, Hikaru; Norisuye, Kazuhiro; Sohrin, Yoshiki; Nakamura, Masaharu
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20262 - 20265
反应条件
in 1,2-dichloro-ethane T=0 - 20°C;
参考文献
Novikov, Mikhail S.; Babkov, Denis A.; Paramonova, Maria P.; Chizhov, Alexander O.; Khandazhinskaya, Anastasia L.; Seley-Radtke, Katherine L.
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 576 - 578
反应条件
sodium methylate in tetrahydrofuran; diethylene glycol dimethyl ether T=40°C; 20 h;
参考文献
Ando, Wataru; Tsumaki, Hidetoshi
Chemistry Letters, 1981 , p. 693 - 694
反应条件
1: N-bromosuccinimide / CCl4 / 24 h / -20 °C 2: CH3OH / 0.02 h View Scheme
参考文献
Ando, Wataru; Tsumaki, Hidetoshi
Synthesis, 1982 , # 4 p. 263 - 264
反应条件
sodium methylate in tetrahydrofuran; diethylene glycol dimethyl ether T=40°C; 24 h;
参考文献
Ando, Wataru; Tsumaki, Hidetoshi
Chemistry Letters, 1981 , p. 693 - 694
反应条件
1: LiClO4 / diethyl ether / 0.5 h 2: LiClO4 / diethyl ether / 2 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 57, # 31 p. 6829 - 6832
反应条件
in hexane 5 h; Ambient temperature;
参考文献
Bowser, James R.; Williams, Pamela J.; Kurz, Kenneth
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4111 - 4113
