3-(4-溴苯基)-2-丙炔-1-醇合成路线 （共 16 条）
反应条件
sodium hydroxide; water in acetone
Combinatorial reaction / High throughput screening (HTS);
参考文献
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITE DE RENNES 1
Patent: US2007/43234 A1, 2007 ;
Location in patent: Page/Page column 58 ;
反应条件
1: 100 percent / Br2 / CCl4
2: 76 percent / 25percent ethanolic KOH / 2.5 h / Heating
3: 1.) EtMgBr / 1.) THF, 45 deg C, 1 h, 2.) THF, 45 deg C, 1 h
View Scheme
参考文献
Blase; Banerjee
Synthetic Communications, 1995 , vol. 25, # 20 p. 3187 - 3197
反应条件
(i) EtMgBr, (ii) /BRN= 1209228/; Multistep reaction;
参考文献
Klemm,L.H. et al.
Journal of Organic Chemistry, 1976 , vol. 41, # 24 p. 3813 - 3819
反应条件
1: 76 percent / 25percent ethanolic KOH / 2.5 h / Heating
2: 1.) EtMgBr / 1.) THF, 45 deg C, 1 h, 2.) THF, 45 deg C, 1 h
View Scheme
参考文献
Blase; Banerjee
Synthetic Communications, 1995 , vol. 25, # 20 p. 3187 - 3197
反应条件
copper diacetate; diisopropylamine; triphenylphosphine; palladium dichloride
3 h; Heating; Title compound not separated from byproducts;
参考文献
Robinson, James M. A.; Kariuki, Benson M.; Harris, Kenneth D. M.; Philp, Douglas
Journal of the Chemical Society. Perkin Transactions 2, 1998 , # 11 p. 2459 - 2469
参考文献
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Patent: US5455260 A1, 1995 ;
US 5455260 A
