1-(4-硝基苯基)-1-丙酮合成路线 （共 24 条）
反应条件
N,N-dimethyl-formamide dimethyl acetal 16 h; Heating;
参考文献
Zhang, Nan; Vozzolo, Joseph
Journal of Organic Chemistry, 2002 , vol. 67, # 5 p. 1703 - 1704
反应条件
hydrogenchloride; tin
参考文献
Uloth; Kirk; Gould; Larsen
Journal of medicinal chemistry, 1966 , vol. 9, # 1 p. 88 - 97
反应条件
1: hydroxylamine hydrochloride, pyridine / methanol / 0.5 h / Heating 2: trifluoroperacetic acid, Na2HPO4, urea / acetonitrile / 1.25 h / Heating View Scheme
参考文献
Galezowski, Wlodzimierz; Jarczewski, Arnold
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1647 - 1656
反应条件
1: ethyl magnesium chloride With zinc(II) chloride in tetrahydrofuran
T=0 - 20°C; 0.5 h;
2: 4-nitro-benzoyl chloride With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=0°C; 0.666667 h;
参考文献
Hirst, Gavin C.; Arnold, Lee D.; Burchat, Andrew; Wishart, Neil; Calderwood, David; Wada, Carol K.; Michaelides, Michael R.; Ji, Zhiqin; Muckey, Melanie
Patent: US2003/225098 A1, 2003 ;
Location in patent: Page 34 ;
US 20030225098 A1
反应条件
1: With copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in acetonitrile
Stille reaction; Heating;
2: With hydrogenchloride in acetonitrile
1 h; Heating;
参考文献
Sato; Narita
Synthesis, 2001 , # 10 p. 1551 - 1555
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride in dimethyl sulfoxide
T=100°C; 14 h;
参考文献
Jean, Mickael; Renaulty, Jacques; Uriac, Philippe; Capet, Marc; Van De Weghe, Pierre
Organic Letters, 2007 , vol. 9, # 18 p. 3623 - 3625
反应条件
[Cp*Ru(CNCH3)3]+PF6-; potassium carbonate in acetonitrile
1 h; Inert atmosphereReflux;
参考文献
Bouziane, Asmae; Carboni, Bertrand; Bruneau, Christian; Carreaux, Francois; Renaud, Jean-Luc
Tetrahedron, 2008 , vol. 64, # 51 p. 11745 - 11750
反应条件
1: N-cyclohexyl-4-nitrobenzamide With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane
T=-78 - 0°C; Inert atmosphere;
2: diethylzinc in dichloromethane
T=0 - 20°C; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran; dichloromethane
T=65°C; 2 h; Inert atmosphere; chemoselective reaction;
参考文献
Bechara, William S.; Pelletier, Guillaume; Charette, Andre B.
Nature Chemistry, 2012 , vol. 4, # 3 p. 228 - 234
反应条件
ammonium acetate in acetic acid
P=760 Torr; 2 h; Heating;
参考文献
Agafonov, N. E.; Sedishev, I. P.; Dudin, A. V.; Kutin, A. A.; Stashina, G. A.; Zhulin, V. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 2.2 p. 366 - 372
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , # 2 p. 426 - 433
反应条件
1: With sodium hydroxide in toluene
1 h;
2: With hydrogenchloride in toluene
T=60 - 95°C; pH=2.5; 5 h; Further stages.;
参考文献
Zimbron, Jeremy Malcolm; Seeger-Weibel, Manuela; Hirt, Hans; Gallou, Fabrice
Synthesis, 2008 , # 8 p. 1221 - 1226
