1,4-双(氯甲基)-2,5-二甲氧基苯合成路线 （共 18 条）
反应条件
hydrogenchloride in water; 2-methyl cyclohexane T=60°C; 8 h;
参考文献
Journal of the Iranian Chemical Society, , vol. 8, # 1 p. 131 - 141
反应条件
hydrogenchloride; formaldehyd T=20°C;
参考文献
DE567753 , ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 550
US1887396 , ;
反应条件
sodium t-butanolate in methanol Substitution; 0.75 h;
参考文献
Journal of Organic Chemistry, , vol. 65, # 2 p. 284 - 289
参考文献
Journal of the American Chemical Society, , vol. 71, p. 393
参考文献
DE567753 , ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 18, p. 550
US1887396 , ;
Biochemical Journal, , vol. 43, p. 606,608
Biochemical Journal, , vol. 57, p. 528
反应条件
1: CHCl3 / 1.) reflux, 30 min, 2.) r.t., overnight 2: 50percent aq. AcOH / 12 h / Heating 3: 1.) 48percent aq. HBr, 2.) aq. HBr, Ac2O / 1.) 130 deg C, 35 h, 2.) reflux, 25 h View Scheme
参考文献
Lee, Sumi; Ahn, Tae-Young; Kim, Sangjun; Jung, Young-Sik; Kim, Jong-Man
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 10 p. 2755 - 2756
反应条件
ethanol; ammonia; sodium in diethyl ether
参考文献
Russkikh, V. S.; Abashev, G. G.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 4 p. 742 - 745
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 4 p. 837 - 841
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in chloroform 16 h; Reflux; 2: With formaldehyd; water 21 h; Reflux;
参考文献
Lee, Sumi; Ahn, Tae-Young; Kim, Sangjun; Jung, Young-Sik; Kim, Jong-Man
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 10 p. 2755 - 2756
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in chloroform Sommelet reaction; 3 h; Heating; 2: With hydrogenchloride T=20°C; Further stages.;
参考文献
Kretz, Tonia; Bats, Jan Willem; Lerner, Hans-Wolfram; Wagner, Matthias
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007 , vol. 62, # 1 p. 66 - 74
反应条件
1: 95 percent / glacial acetic acid / Heating
2: 94 percent / NaOH, H20 / tetrahydrofuran; methanol / Heating
3: 82 percent / phosphorous tribromide / tetrahydrofuran / a) 0 deg C, 10 min, b) r.t., 4 h
View Scheme
参考文献
Witiak; Loper; Ananthan; Almerico; Verhoef; Filppi
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1636 - 1642
