4-硝基-3-己烷基乙酸酯合成路线 （共 17 条）
反应条件
1: 100 percent / P(MeNCH2CH2)3N / tetrahydrofuran; propan-2-ol / 2 h / -20 - -15 °C 2: 17 percent / aq. LiCl, O2 / dimethylsulfoxide / 4 h / 190 - 200 °C View Scheme
参考文献
Ono, Noboru; Kawamura, Hisayuki; Bougauchi, Masahiro; Maruyama, Kazuhiro
Tetrahedron, 1990 , vol. 46, # 21 p. 7483 - 7496
反应条件
1: 81 percent / potassium carbonate / tetrahydrofuran; ethanol / 72 h / 20 °C 2: 88 percent / NaOH / ethanol; H2O / Heating 3: 71 percent / trifluoroacetic acid / 1 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 45 p. 11030 - 11039
反应条件
1.1: potassium carbonate / tetrahydrofuran; ethanol / 72 h / 20 °C 2.1: sodium hydroxide / ethylene glycol / 1 h / |Reflux 3.1: trichlorophosphate / 0 °C / |Inert atmosphere 3.2: 10 h / 20 °C / |Inert atmosphere 3.3: 1 h / 20 °C View Scheme
参考文献
Kancharla, Papireddy; Reynolds, Kevin A.
Tetrahedron, 2013 , vol. 69, # 39 p. 8375 - 8385
反应条件
1: 81 percent / potassium carbonate / tetrahydrofuran; ethanol / 72 h / 20 °C 2: 88 percent / NaOH / ethanol; H2O / Heating View Scheme
参考文献
Roth, Steven D.; Shkindel, Tetyana; Lightner, David A.
Tetrahedron, 2007 , vol. 63, # 45 p. 11030 - 11039
反应条件
1: 81 percent / potassium carbonate / tetrahydrofuran; ethanol / 72 h / 20 °C 2: 88 percent / NaOH / ethanol; H2O / Heating 3: 68 percent / H2O / Heating View Scheme
参考文献
Tang; Verkade
Journal of Organic Chemistry, 1994 , vol. 59, # 25 p. 7793 - 7802
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
3 h; Ambient temperature;
参考文献
Bhattacharya, Apurba; Cherukuri, Sankara; Plata, Robert Erik; Patel, Nitinchandra; Tamez Jr., Victoriano; Grosso, John A.; Peddicord, Michael; Palaniswamy, Venkatapuram A.
Tetrahedron Letters, 2006 , vol. 47, # 31 p. 5481 - 5484
反应条件
sulfuric acid; acetic anhydride; sodium hydrogencarbonate in chloroform
参考文献
CANON KABUSHIKI KAISHA; EHIME UNIVERSITY
Patent: US2008/171403 A1, 2008 ;
反应条件
1: propionaldehyde; 1-nitro-propane With 4-(N,N-dimethlyamino)pyridine
T=10 - 20°C;
2: acetic anhydride in dichloromethane
T=20°C; 24 h;
参考文献
Matsuo, Takashi; Hayashi, Akihiro; Abe, Masato; Matsuda, Takaaki; Hisaeda, Yoshio; Hayashi, Takashi
Journal of the American Chemical Society, 2009 , vol. 131, # 42 p. 15124 - 15125
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 6 h; Inert atmosphere;
参考文献
Kancharla, Papireddy; Reynolds, Kevin A.
Tetrahedron, 2013 , vol. 69, # 39 p. 8375 - 8385
反应条件
sodium hydroxide; sodium dithionite; sodium acetate; silver nitrate in chloroform
参考文献
Pagano,A.H.; Shechter,H.
Journal of Organic Chemistry, 1970 , vol. 35, p. 295 - 303
