4,4’-(丙烷-1,3-二基双(氧基))二苯甲醛合成路线 （共 7 条）
反应条件
potassium hydroxide; potassium permanganate
参考文献
Neish
Recueil des Travaux Chimiques des Pays-Bas, 1947 , vol. 66, p. 433,440
反应条件
potassium carbonate in acetonitrile
T=20 - 60°C; 3 - 4 h; Industry scale;
参考文献
DESTINY PHARMA LIMITED; SOLVIAS AG
Patent: WO2007/74340 A1, 2007 ;
Location in patent: Page/Page column title page; 18-20; Sheet 1/2 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=100°C; 12 h;
参考文献
Kueny-Stotz, Marie; Brouillard, Raymond; Chassaing, Stefan
Synlett, 2012 , vol. 23, # 14 p. 2053 - 2058,6
Title/Abstract Full Text Show Details
Kueny-Stotz, Marie; Brouillard, Raymond; Chassaing, Stefan
Synlett, 2012 , vol. 23, # 14 p. 2053 - 2058
反应条件
hydrogenchloride; aluminium trichloride; benzene
Zersetzung des Reaktionsproduktes durch Kochen mit verd. Salzsaeure;
参考文献
Gattermann
Justus Liebigs Annalen der Chemie, 1907 , vol. 357, p. 373
反应条件
sodium ethanolate
1.) ethanol, reflux, 4 h, 2.) reflux, 48 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
参考文献
Gattermann
Justus Liebigs Annalen der Chemie, 1907 , vol. 357, p. 373
反应条件
1: 82.3 percent / piperidine, glacial acetic acid / benzene / Heating
2: 2.) NaOH / 1.) water, ethanol, heating, 2 h, 2.) ethylene glycol, heating, 40 h
View Scheme
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
