乙基5,5-二甲基-4-氧代己酸酯合成路线 （共 8 条）
反应条件
water; trifluoroacetic acid in dichloromethane T=20°C; 10.5 h;
参考文献
Sato, Tsuneo; Okazaki, Hiroshi; Otera, Junzo; Nozaki, Hitosi
Journal of the American Chemical Society, 1988 , vol. 110, # 15 p. 5209 - 5211
反应条件
1: diiodomethane With diethylzinc; trifluoroacetic acid in dichloromethane 0.5 h; 2: ethyl 4,4-dimethyl-3-oxo-pentoate in dichloromethane T=20°C; 7 h;
参考文献
Xue, Song; Liu, Yong-Kang; Li, Le-Zhen; Guo, Qing-Xiang
Journal of Organic Chemistry, 2005 , vol. 70, # 20 p. 8245 - 8247
反应条件
1: 2) t-BuOK / 1) THF, 50 deg C, 12 h; 2) THF, -78 deg C, 0.5 h 2: 82 percent / CF3COOH, H2O / CH2Cl2 / 10.5 h / 20 °C View Scheme
参考文献
Sato, Tsuneo; Okazaki, Hiroshi; Otera, Junzo; Nozaki, Hitosi
Journal of the American Chemical Society, 1988 , vol. 110, # 15 p. 5209 - 5211
反应条件
1: 88 percent / MeSO2Cl, Et3N / benzene / 12 h / 20 °C 2: 2) t-BuOK / 1) THF, 50 deg C, 12 h; 2) THF, -78 deg C, 0.5 h 3: 82 percent / CF3COOH, H2O / CH2Cl2 / 10.5 h / 20 °C View Scheme
参考文献
Sato, Tsuneo; Okazaki, Hiroshi; Otera, Junzo; Nozaki, Hitosi
Journal of the American Chemical Society, 1988 , vol. 110, # 15 p. 5209 - 5211
反应条件
nickel P=73550.8 Torr; Hydrogenation.Zuletzt bei 100gradC;
参考文献
McElvain; Taylor
Journal of the American Chemical Society, 1941 , vol. 63, p. 2514
参考文献
Sato, Azusa; Ito, Hisanaka; Yamaguchi, Yusuke; Taguchi, Takeo
Tetrahedron Letters, 2000 , vol. 41, # 52 p. 10239 - 10243
反应条件
in diethyl ether; hexane 2.5 h; Ambient temperature;
参考文献
Hopf, Henning; Haenel, Ralf
Chemische Berichte, 1994 , vol. 127, # 11 p. 2347 - 2348
参考文献
Nilsson,L.; Rappe,C.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1976 , vol. 30, p. 1000 - 1001
