2-氨基-6-甲基-N-邻甲苯苯甲酰胺合成路线 (共 4 条)
反应条件
in chloroform
3 h; Heating / reflux;
参考文献
ICOS Corporation
Patent: US6667300 B2, 2003 ;
Location in patent: Page column 65-66 ;
US 6667300 B2
反应条件
1: 2-amino-6-methyl-benzoic acid With thionyl chloride in toluene
1 h; Heating;
2: o-toluidine in tetrahydrofuran
18 h; Heating; Further stages.;
参考文献
Zhichkin, Paul; Kesicki, Edward; Treiberg, Jennifer; Bourdon, Lisa; Ronsheim, Matthew; Ooi, Hua Chee; White, Stephen; Judkins, Angela; Fairfax, David
Organic Letters, 2007 , vol. 9, # 7 p. 1415 - 1418
反应条件
1: thionyl chloride / toluene / 1 h / 110 °C
2: tetrahydrofuran / 2 h / 0 - 80 °C
View Scheme
参考文献
EXELIXIS, INC.; LEAHY, James, William
Patent: WO2012/37204 A1, 2012 ;
WO 2012/037204 A1
反应条件
1: ethyl acetate; acetic acid
2: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
INTELLIKINE, INC.
Patent: US2011/269779 A1, 2011 ;