2-巯基-5-甲氧基苯并咪唑合成路线 （共 25 条）
反应条件
1: 85 percent / acetic acid / 2 h / 110 °C 2: 91 percent / nitric acid; sulfuric acid / 0 - 5 °C 3: Na2S*9H2O / 6 h / Heating 4: 40 percent / potassium hydroxide / ethanol; H2O / 6 h / Heating View Scheme
参考文献
Mahajan; Nandre
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 7 p. 1756 - 1758
反应条件
1: 96 percent / Na2S*9H2O / H2O / 6 h / Heating 2: 40 percent / potassium hydroxide / ethanol; H2O / 6 h / Heating View Scheme
参考文献
Mahajan; Nandre
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 7 p. 1756 - 1758
反应条件
Microwave irradiation;
参考文献
Mahesh Kumar; Dubey
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 11 p. 1619 - 1622
反应条件
sodium hydroxide in methanol; water 1 h; Heating;
参考文献
Uchida; Morita; Chihiro; Kanbe; Yamasaki; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1517 - 1523
反应条件
sodium hydroxide; dihydrogen peroxide 1) 0 deg C, 30 min, 2) RT, 2 h;
参考文献
Sorba; Garrone; Serafino; et al.
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 391 - 395
反应条件
dihydrogen peroxide in water T=-10°C; Inert atmosphere;
参考文献
Bhalerao, Dinesh S.; Kondaiah, Golla China Mala; Dwivedi, Namrata; Mylavarappu, Ravi Kumar; Reddy, Lekkala Amarnath; Roy, Arnab; Nagaraju, Gudimalla; Reddy, Padi Pratap; Bhattacharya, Apurba; Bandichhor, Rakeshwar
Synthetic Communications, 2010 , vol. 40, # 20 p. 2983 - 2987
反应条件
dihydrogen peroxide in water T=-10°C; Inert atmosphere;
参考文献
Bhalerao, Dinesh S.; Kondaiah, Golla China Mala; Dwivedi, Namrata; Mylavarappu, Ravi Kumar; Reddy, Lekkala Amarnath; Roy, Arnab; Nagaraju, Gudimalla; Reddy, Padi Pratap; Bhattacharya, Apurba; Bandichhor, Rakeshwar
Synthetic Communications, 2010 , vol. 40, # 20 p. 2983 - 2987
反应条件
dihydrogen peroxide in water T=-10°C; Inert atmosphere;
参考文献
Bhalerao, Dinesh S.; Kondaiah, Golla China Mala; Dwivedi, Namrata; Mylavarappu, Ravi Kumar; Reddy, Lekkala Amarnath; Roy, Arnab; Nagaraju, Gudimalla; Reddy, Padi Pratap; Bhattacharya, Apurba; Bandichhor, Rakeshwar
Synthetic Communications, 2010 , vol. 40, # 20 p. 2983 - 2987
反应条件
sodium carbonate in methanol Reflux;
参考文献
ORCHID CHEMICALS and PHARMACEUTICALS LTD; REGURI, Buchi Reddy; UPPARAPALLI, Sampathkumar; SIVADAS, Anand; VIGNESWARA CHELLAM, Ravisankar; SHANMUGA SUNDARAM, Bharani Kumar; SUBBAIAH, Ramesh
Patent: WO2011/12957 A1, 2011 ;
Location in patent: Page/Page column 16 ;
反应条件
1: (4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl alcohol With thionyl chloride in water; toluene T=25 - 35°C; 1 h; 2: 2-mercapto-5-methoxy-1H-benzimidazole With sodium hydroxide in water; toluene T=45°C; pH=> 12.5; 2 h;
参考文献
Astrazeneca AB
Patent: WO2004/35565 A1, 2004 ;
Location in patent: Page 5; 8-9 ;
