1-氟-4-(2-苯基乙基)苯合成路线 （共 14 条）
反应条件
1: With sodium acetate in N,N-dimethyl acetamide
T=100°C; Heck reaction; Inert atmosphere;
2: With hydrogen in N,N-dimethyl acetamide
T=20°C; P=760.051 Torr;
参考文献
Kantam, M. Lakshmi; Chakravarti, Rajashree; Chintareddy, Venkat Reddy; Sreedhar; Bhargava, Suresh
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2544 - 2550
反应条件
1-methyl-pyrrolidin-2-one; palladium diacetate; tri-cyclo-hexyl-phosphine in tetrahydrofuran
T=20°C; Kumada coupling; 20 h;
参考文献
Frisch, Anja C.; Shaikh, Nadim; Zapf, Alexander; Belier, Matthias
Angewandte Chemie - International Edition, 2002 , vol. 41, # 21 p. 4056 - 4059
反应条件
N,N,N',N,-tetramethylethylenediamine; ((Me)N2N)Ni-Cl in tetrahydrofuran
T=20°C; Kumada-Corriu-Tamao coupling reaction; 2 h; Inert atmosphere;
参考文献
Vechorkin, Oleg; Proust, Valerie; Hu, Xile
Journal of the American Chemical Society, 2009 , vol. 131, # 28 p. 9756 - 9766
反应条件
potassium tert-butylate; palladium diacetate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine in water; toluene
T=80°C; Suzuki-Miyaura Coupling; 24 h; Schlenk techniqueGloveboxInert atmosphere;
参考文献
Zhang, Lei; Zuo, Ziqing; Leng, Xuebing; Huang, Zheng
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2696 - 2700
Angew. Chem., 2014 , vol. 126, # 10 p. 2734 - 2738,5
反应条件
pyridine; MeCH=CHCO2Et; nickel dichloride; zinc in acetonitrile
T=20°C; 8 h; Inert atmosphere;
参考文献
Yan, Chang-Song; Peng, Yu; Xu, Xiao-Bo; Wang, Ya-Wen
Chemistry - A European Journal, 2012 , vol. 18, # 19 p. 6039 - 6048
反应条件
hydrogen; palladium on activated charcoal
参考文献
Gascoyne,J.M. et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977 , p. 1051 - 1057
反应条件
hydrogen; palladium on activated charcoal
参考文献
Gascoyne,J.M. et al.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1977 , p. 1051 - 1057
反应条件
1: (iPrPNN)CoCl2; NaBEt3H / tetrahydrofuran; toluene / 0.25 h / 25 °C / |Inert atmosphere; |Glovebox; |Schlenk technique
2: palladium diacetate; potassium tert-butylate; dicyclohexyl(2',6'-diisopropoxy-[1,1'-biphenyl]-2-yl)phosphine / toluene; water / 24 h / 80 °C / |Schlenk technique; |Glovebox; |Inert atmosphere
View Scheme
参考文献
Zhang, Lei; Zuo, Ziqing; Leng, Xuebing; Huang, Zheng
Angewandte Chemie - International Edition, 2014 , vol. 53, # 10 p. 2696 - 2700
Angew. Chem., 2014 , vol. 126, # 10 p. 2734 - 2738,5
反应条件
(i), (ii) KOH, N2H4; Multistep reaction;
参考文献
Pews,R.G.; Ojha,N.D.
Journal of the American Chemical Society, 1969 , vol. 91, # 21 p. 5769 - 5773
反应条件
ethanol; nickel
Hydrogenation;
参考文献
Rooney; Bourns
Canadian Journal of Chemistry, 1955 , vol. 33, p. 1633,1636
