1,4-苯并二烷-2-羧酸合成路线 （共 16 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran 3 h;
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
反应条件
sulfuric acid; acetic acid in water T=110°C; 15 h;
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
参考文献
Journal of the American Chemical Society, , vol. 77, p. 5373
反应条件
1: 85 percent / K2CO3 / acetone / 12 h / Heating 2: 98 percent / HOAc, conc. H2SO4 / H2O / 15 h / 110 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 8 p. 1988 - 1996
反应条件
T=150°C; anschl. mit methanol. KOH;
参考文献
Journal of the Chemical Society, , p. 2136,2138
反应条件
sulfuric acid; hydrazine hydrate T=80°C; 5 h;
参考文献
Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 20 p. 6048 - 6058
反应条件
sulfuric acid 1 h; Heating;
参考文献
Tomiyama; Wakabayashi; Yokota
Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1988 - 1996
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 4 h;
参考文献
FENG, Yangbo; LOGRASSO, Philip; BANNISTER, Thomas; SCHROETER, Thomas; FANG, Xingang; YIN, Yan; CHEN, Yen Ting; SESSIONS, Hampton; CHOWDHURY, Sarwat; LUO, Jun-Li; VOJKOVSKY, Tomas
Patent: WO2010/56758 A1, 2010 ;
Location in patent: Page/Page column 50-51 ;
WO 2010/056758 A1
反应条件
2: LAH / tetrahydrofuran View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 1 p. 49 - 57
反应条件
1: 2,3-dihydro-1,4-benzodioxin-2-carboxylic acid With N-bromosuccinmide; triphenylphosphine in dichloromethane T=0 - 5°C; 0.25 h; 2: piperazine With pyridine in dichloromethane T=20°C; 0.5 h;
参考文献
Bandgar; Bettigeri
Synthetic Communications, 2004 , vol. 34, # 16 p. 2917 - 2924
