2-(羧乙基)三苯基氯化膦合成路线 （共 11 条）
反应条件
in toluene T=110°C; 18 h;
参考文献
Constant-Urban, Celine; Charif, Mounia; Goffin, Eric; Van Heugen, Jean-Claude; Elmoualij, Benaissa; Chiap, Patrice; Mouithys-Mickalad, Ange; Serteyn, Didier; Lebrun, Philippe; Pirotte, Bernard; De Tullio, Pascal
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5878 - 5881
反应条件
1: 19 percent / NaH / 1.) DMSO, 0 deg C, 10 min, 2.) THF, room temp., 4 d, 3.) aq. HCl 2: 89 percent / xylene / 18 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 11 p. 2240 - 2243
反应条件
water in dichloromethane; acetone
参考文献
Helvetica Chimica Acta, , vol. 46, p. 2178 - 2185
反应条件
in benzene T=50°C; 20 h; Title compound not separated from byproducts.;
参考文献
Russian Journal of General Chemistry, , vol. 75, # 12 p. 1889 - 1894
反应条件
potassium tert-butylate in tetrahydrofuran 10 h; Ambient temperature;
参考文献
Ozaki; Matsukura; Kabasawa; Ishibashi; Ikemori; Hamano; Minami
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 10 p. 2735 - 2740
反应条件
1: (2-carboxyethyl)triphenylphosphonium chloride; benzaldehyde With potassium tert-butylate in tetrahydrofuran T=-10 - 20°C; Inert atmosphere; 2: dimethyl sulfate in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Hansen, Joorn H.; Parr, Brendan T.; Pelphrey, Philip; Jin, Quihui; Autschbach, Jochen; Davies, Huw M. L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 11 p. 2544 - 2548
反应条件
sodium hydride in tetrahydrofuran; dimethyl sulfoxide
参考文献
Polivka, Zdenek; Licha, Irena; Taufmann, Petr; Svatek, Emil; Holubek, Jiri; Protiva, Miroslav
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 6 p. 1566 - 1581
反应条件
1: 52 percent / NaH / tetrahydrofuran; dimethylsulfoxide / Ambient temperature
2: 94 percent / H2 / 10percent Pd/C / ethanol / 1551.4 Torr
3: PCl5 / benzene / 1 h
4: SnCl4 / benzene / 0.25 h / 0 °C
View Scheme
参考文献
Zhang, Xiaoyan; De Los Angeles, Joseph E.; He, Mei-Ying; Dalton, James T.; Shams, Gamal; Lei, Longping; Patil, Popat N.; Feller, Dennis R.; Miller, Duane D.; Hsu, Fu-Lian
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3014 - 3024
反应条件
1: 52 percent / NaH / tetrahydrofuran; dimethylsulfoxide / Ambient temperature
2: 94 percent / H2 / 10percent Pd/C / ethanol / 1551.4 Torr
View Scheme
参考文献
Zhang, Xiaoyan; De Los Angeles, Joseph E.; He, Mei-Ying; Dalton, James T.; Shams, Gamal; Lei, Longping; Patil, Popat N.; Feller, Dennis R.; Miller, Duane D.; Hsu, Fu-Lian
Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3014 - 3024
反应条件
sodium hydrogencarbonate in ethanol; water
参考文献
Galkin; Bakhtiyarova; Polezhaeva; Shaikhutdinov; Klochkov; Cherkasov
Russian Journal of General Chemistry, 1998 , vol. 68, # 7 p. 1052 - 1056
