(S)-3-羟基-3-苯基丙酸甲酯合成路线 （共 42 条）
反应条件
1: With chloro-trimethyl-silane; zinc in tetrahydrofuran T=20 - 55°C; 0.25 h; 2: bromoacetic acid methyl ester in tetrahydrofuran T=45°C; 0.283333 h; 3: benzaldehyde With hydrogenchloride; ammonia; water; (+)-sparteine more than 3 stages;
参考文献
Consortium fuer elektrochemische Industrie GmbH
Patent: US6924386 B2, 2005 ;
Location in patent: Page/Page column 14-16 ;
反应条件
hydrogen; C2H8N(1+)*C76H57Cl5O8P4Ru2(1-) in methanol T=80°C; 5.5 h; autoclave;
参考文献
Takasago International Corporation
Patent: EP1176135 A1, 2002 ;
Location in patent: Example 1 ;
反应条件
sodium peroxoborate tetrahydrate; water in tetrahydrofuran T=20°C; 0.3 h;
参考文献
Tetrahedron, , vol. 69, # 17 p. 3551 - 3560
反应条件
potassium hydrogencarbonate in acetone T=60°C; 24 h;
参考文献
Boaz, Neil W.
Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4289 - 4292
反应条件
Burkholderia cepacia amano PS-IM lipase in tert-butyl methyl ether T=30°C; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 925 - 936
反应条件
lithium borohydride; N,N'-bis(benzoyl)-L-cystine; tert-butyl alcohol in tetrahydrofuran T=-78 - -30°C; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 3 p. 138 - 139
反应条件
Burkholderia cepacia amano PS-IM lipase in toluene T=30°C; Resolution of racemateEnzymatic reaction; Reagent/catalystSolvent; enantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 925 - 936
反应条件
immobilised Candida parapsilosis ATCC 7330 whole cells in methanol; water T=25°C; 6 h;
参考文献
Padhi, Santosh Kumar; Titu; Pandian, N. Ganesh; Chadha, Anju
Tetrahedron, 2006 , vol. 62, # 21 p. 5133 - 5140
反应条件
hydrogenchloride; acetyl chloride in water T=0°C; 6 h; Reflux;
参考文献
Watanabe, Yudai; Washio, Takuya; Krishnamurthi, Janagiraman; Anada, Masahiro; Hashimoto, Shunichi
Chemical Communications, 2012 , vol. 48, # 55 p. 6969 - 6971
反应条件
in methanol T=0°C; 0.5 h;
参考文献
Chemistry Letters, , p. 787 - 790
