1-二苯甲基-3-氰基氮杂环丁烷合成路线 （共 14 条）
反应条件
in water; N,N-dimethyl-formamide T=65°C; 9 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 48 ;
EP 2119706 A1
反应条件
in water; N,N-dimethyl-formamide T=65°C; 9 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1889836 A1, 2008 ;
Location in patent: Page/Page column 79 ;
反应条件
in water; N,N-dimethyl-formamide T=65°C; 9 h;
参考文献
Eisai RandD Management Co., Ltd.
Patent: US2008/214815 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
in water; N,N-dimethyl-formamide T=90°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
in dichloromethane; di-isopropyl ether; water; N,N-dimethyl-formamide
反应条件
1: triethylamine / CH2Cl2 / Ambient temperature 2: dimethylformamide / 6 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 7 p. 801 - 810
反应条件
1: ethanol / 144 h / 20 °C / Reflux 2: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 3: water; N,N-dimethyl-formamide / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 20 p. 6031 - 6035
反应条件
1: With potassium hydroxide; water in 2-methoxy-ethanol T=100°C; 4 h; 2: With hydrogenchloride in 2-methoxy-ethanol; water pH=5;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 48 ;
EP 2119706 A1
反应条件
sulfuric acid in methanol
参考文献
Shionogi and Co., Ltd.
Patent: US4200628 A1, 1980 ;
反应条件
sulfuric acid T=90°C; 2 h;
参考文献
Morley, Andrew; Tomkinson, Nicholas; Cook, Andrew; MacDonald, Catherine; Weaver, Richard; King, Sarah; Jenkinson, Lesley; Unitt, John; McCrae, Christopher; Phillips, Tim
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 20 p. 6031 - 6035
