(E)-3-(2,2-二甲基-[1,3]二氧杂烷-4-基)-丙烯酸乙酯合成路线 （共 25 条）
反应条件
potassium carbonate in tetrahydrofuran; water T=20°C; Horner-Wadsworth-Emmons reaction; pH=11.6; 17 h;
参考文献
Quaedflieg, Peter J. L. M.; Kesteleyn, Bart R. R.; Wigerinck, Piet B. T. P.; Goyvaerts, Nicolaas M. F.; Vijn, Robert Jan; Liebregts, Constantinus S. M.; Kooistra, Jaap H. M. H.; Cusan, Claudia
Organic Letters, 2005 , vol. 7, # 26 p. 5917 - 5920
反应条件
1: 1,2,5,6-diisopropylidine-D-manitol With sodium periodate; sodium carbonate in water T=0 - 22°C; 1 h; 2: diethoxyphosphoryl-acetic acid ethyl ester With potassium carbonate in water 18 h; Further stages.;
参考文献
Powell, Sharon A.; Tenenbaum, Jason M.; Woerpel
Journal of the American Chemical Society, 2002 , vol. 124, # 43 p. 12648 - 12649
反应条件
in benzene Wittig reaction; Reflux;
参考文献
Hubschwerlen, Christian
Synthesis, 1986 , # 11 p. 962 - 964
反应条件
1: 5,6-O-isopropylidene-L-gulonic acid γ-lactone With sodium periodate; sodium hydroxide in water pH=5.5; 1 h; Inert atmosphereCooling with ice; 2: ethyl (triphenylphosphoranylidene)acetate in dichloromethane; water T=20°C; 10 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Enev, Valentin S.; Felzmann, Wolfgang; Gromov, Alexey; Marchart, Stefan; Mulzer, Johann
Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9651 - 9668
反应条件
potassium tert-butylate in tetrahydrofuran T=-78°C;
参考文献
Oi, Ryu; Sharpless, K. Barry
Tetrahedron Letters, 1992 , vol. 33, # 16 p. 2095 - 2098
反应条件
1: 1) (COCl)2, DMSO, 2) Et3N / 1) CH2Cl2, -65 deg C, 10 min, 2a) -65 deg C, 5 min, b) to -10 deg C 2: methanol / 20 h / -10 °C View Scheme
参考文献
Janson; Kvarnstrom; Svensson; Classon; Samuelsson
Synthesis, 1993 , # 1 p. 129 - 133
反应条件
1: 69 percent / NaIO4 / H2O / 2 h / Ambient temperature 2: 23 percent / CH2Cl2 / Ambient temperature View Scheme
参考文献
Hubschwerlen, Christian
Synthesis, 1986 , # 11 p. 962 - 964
反应条件
in dichloromethane T=20°C; Wittig olefination; 9 h;
参考文献
Sharma; Punna, Sreenivas; Rajendra Prasad; Krishna, Palakodety Radna; Chorghade, Mukund S.; Ley, Steven V.
Tetrahedron Asymmetry, 2005 , vol. 16, # 6 p. 1113 - 1123
反应条件
1.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice 2.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 2.2: 10 h / 20 °C / Inert atmosphere View Scheme
参考文献
Enev, Valentin S.; Felzmann, Wolfgang; Gromov, Alexey; Marchart, Stefan; Mulzer, Johann
Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9651 - 9668
反应条件
1.1: palladium 10 on activated carbon; hydrogen / water / 50 °C / 2585.81 Torr 2.1: sulfuric acid / N,N-dimethyl-formamide / 8 h / 20 °C / pH 3 / Inert atmosphere; Cooling with ice 3.1: sodium periodate; sodium hydroxide / water / 1 h / pH 5.5 / Inert atmosphere; Cooling with ice 3.2: 10 h / 20 °C / Inert atmosphere View Scheme
参考文献
Enev, Valentin S.; Felzmann, Wolfgang; Gromov, Alexey; Marchart, Stefan; Mulzer, Johann
Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9651 - 9668
