4-氰基-1-甲基-4-苯基哌啶合成路线 （共 11 条）
反应条件
1: aqueous H2SO4 2: bromine; aqueous KOH View Scheme
参考文献
Chiavarelli; Marini-Bettolo
Rend. Ist. super. Sanita, 1955 , vol. 18, p. 1014,1019
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran 2 h; 2: With water; sodium sulfate in tetrahydrofuran 0.5 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/124757 A1, 2008 ;
Location in patent: Page/Page column 53-54 ;
WO 2008/124757 A1
反应条件
nickel T=100°C; P=66195.7 Torr; Hydrogenation;
参考文献
Chiavarelli; Marini-Bettolo
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 515,521, 523
反应条件
T=-15°C; Hydrogenation;
参考文献
Chiavarelli; Marini-Bettolo
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 515,521, 523
反应条件
sulfuric acid Heating;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2011/160244 A1, 2011 ;
Location in patent: Page/Page column 11 ;
US 20110160244 A1
反应条件
sulfuric acid Erhitzen des Reaktionsgemisches mit Aethanol (Ueberschuss) unter Abdestillieren von H2O und Aethanol;
参考文献
Eisleb
Chemische Berichte, 1941 , vol. 74, p. 1433,1449
反应条件
hydrogenchloride; water Heating / reflux;
参考文献
NeuroMed Technologies Inc.
Patent: US2006/63775 A1, 2006 ;
Location in patent: Page/Page column 17 ;
US 20060063775 A1
反应条件
potassium hydroxide T=160 - 170°C;
参考文献
Hoffmann-La Roche
Patent: US2418289 , 1942 ;
Full Text Show Details
Roche Prod. Ltd.
Patent: DE882403 , 1950 ;
DRP/DRBP Org.Chem.
反应条件
1: sodium; ethanol / 0 °C
View Scheme
参考文献
Blicke; Tsao
Journal of the American Chemical Society, 1953 , vol. 75, p. 5417
反应条件
diethyl ether; toluene
Behandeln des Reaktionsgemisches mit wss.Salzsaeure;
参考文献
Mercer, Susan L.; Cunningham, Christopher W.; Eddington, Natalie D.; Coop, Andrew
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 12 p. 3638 - 3640
