3-乙酰基二氢-5-甲基-2(3H)-呋喃酮合成路线 （共 12 条）
反应条件
triethylamine in ethanol T=80°C; 2.33333 h;
参考文献
Lonza AG
Patent: EP1911752 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
sodium in ethanol 1.) 0 degC overnight, 2.) R.T. 4 h;
参考文献
Cornish Christopher A.; Warren, Stuart
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2585 - 2598
反应条件
hydrogenchloride; sodium hydroxide; methyloxirane
参考文献
QUANTUM CHEMICAL CORPORATION (a Virginia corp.)
Patent: EP348549 A1, 1990 ;
参考文献
Adams; VanderWerf
Journal of the American Chemical Society, 1950 , vol. 72, p. 4368,4371
Full Text Show Details
Zuidema et al.
Org. Synth. Coll. Vol., 1963 , vol. IV, p. 10,12
参考文献
Adams; VanderWerf
Journal of the American Chemical Society, 1950 , vol. 72, p. 4368,4371
反应条件
n-butyllithium; sodium hydride 1.) THF, HMPA, -12 - 0 deg C -> 25 deg C; 25 deg C, 20 min, 2.) THF, HMPA, hexane, -15 - 0 deg C -> 25 deg C, 25 deg C, 0.5 h, 3.) -15 - 4 deg C, 30 min, RT, 3 h;
参考文献
Reddy, R. Thimma; Nayak, U. R.
Synthetic Communications, 1986 , vol. 16, # 6 p. 713 - 722
反应条件
1: 45 percent / 1.) NaH, 2.) n-BuLi / 1.) THF-HMPA, -12 - 0 deg C -> 25 deg C; 25 deg C, 20 min, 2.) THF-HMPA-hexane, -15 - 0 deg C -> 25 deg C, 25 deg C, 0.5 h, 3.) -15 - 4 deg C; 0 deg C, 1 h 2: 85 percent / KOH / methanol; H2O / 10 h / Heating 3: 72 percent / PCC / CH2Cl2 / 6 h / Ambient temperature 4: 75 percent / NaOH / aq. ethanol / 18 h / Ambient temperature 5: 90 percent / H2 / Pd-CaCO3 / hexane View Scheme
参考文献
Reddy, R. Thimma; Nayak, U. R.
Synthetic Communications, 1986 , vol. 16, # 6 p. 713 - 722
反应条件
1: 55 percent / 1.) NaH, 2.) n-BuLi / 1.) THF, HMPA, -12 - 0 deg C -> 25 deg C; 25 deg C, 20 min, 2.) THF, HMPA, hexane, -15 - 0 deg C -> 25 deg C, 25 deg C, 0.5 h, 3.) -15 - 4 deg C, 30 min, RT, 3 h 2: 80 percent / KOH / methanol; H2O / 10 h / Heating 3: 75 percent / PCC / CH2Cl2 / 6 h / Ambient temperature 4: 70 percent / NaOH / aq. ethanol / 6 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 16, # 6 p. 713 - 722
反应条件
1: pyridine / Co2(CO)8 / benzene / 6 h / 140 °C 2: NH2OH*HCl, CH3COOH / 12 h / Heating View Scheme
参考文献
Chatani,N.; Fujii,S.; Yamasaki,Y.
Journal of the American Chemical Society, 1986 , vol. 108, p. 7361
反应条件
1: 55 percent / 1.) NaH, 2.) n-BuLi / 1.) THF, HMPA, -12 - 0 deg C -> 25 deg C; 25 deg C, 20 min, 2.) THF, HMPA, hexane, -15 - 0 deg C -> 25 deg C, 25 deg C, 0.5 h, 3.) -15 - 4 deg C, 30 min, RT, 3 h
2: 80 percent / KOH / methanol; H2O / 10 h / Heating
3: 75 percent / PCC / CH2Cl2 / 6 h / Ambient temperature
View Scheme
参考文献
Reddy, R. Thimma; Nayak, U. R.
Synthetic Communications, 1986 , vol. 16, # 6 p. 713 - 722
