4-(N-[2,4-二氨基-6-喋啶甲基]-氨基)苯酸钠盐合成路线 （共 14 条）
反应条件
1: With bromine; triphenylphosphine in isobutyramide T=8°C; 0.75 h; 2: 4-amino-4-deoxy-6-hydroxymethylpteridine in isobutyramide T=20°C; 18 h; 3: 4-amino-benzoic acid With BaO in isobutyramide T=53 - 57°C; 22 - 26 h;
参考文献
Rosowsky, Andre; Bader, Henry; Blumbergs, Peter; Lin, Ming-Teh
Patent: US2004/72837 A1, 2004 ;
Location in patent: Page/Page column 7-8 ;
反应条件
sodium hydrogencarbonate in water T=85°C;
参考文献
Rosowsky, Andre; Bader, Henry; Blumbergs, Peter; Lin, Ming-Teh
Patent: US2004/72837 A1, 2004 ;
Location in patent: Page/Page column 8 ;
反应条件
in methanol; dichloromethane; water
参考文献
Rosenwald, Lindsay A.; Weiser, Michael; Stein, Jason; Serbin, Jeff
Patent: US2005/32807 A1, 2005 ;
反应条件
sodium hydroxide; sodium acetate; acetic acid; zinc(II) chloride T=37°C; 24 h; carboxypeptidase G1;
参考文献
Rosowsky, Andre; Forsch, Ronald A.; Freisheim, James H.; Moran, Richard G.; Wick, Michael
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 600 - 604
反应条件
BaO in N,N-dimethyl acetamide T=55°C; 24 h;
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
1: H2 / 5percent palladium on carbon / methanol / 18 h / 1292.9 Torr 2: 80 percent / methanol / 4 h / Heating 3: 86 percent / 0.1 N HCl / trifluoroacetic acid / 55 °C View Scheme
参考文献
Nair; Adapa; Bridges
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3152 - 3155
反应条件
1: 84 percent / 1 N NaOH / tetrahydrofuran / 18 h 2: H2 / 5percent palladium on carbon / methanol / 18 h / 1292.9 Torr 3: 80 percent / methanol / 4 h / Heating 4: 86 percent / 0.1 N HCl / trifluoroacetic acid / 55 °C View Scheme
参考文献
Nair; Adapa; Bridges
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3152 - 3155
反应条件
1: Br2, triphenylphosphine / N,N-dimethyl-acetamide / 18 h / 25 °C 2: BaO / N,N-dimethyl-acetamide / 24 h / 55 °C View Scheme
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
1: 80 percent / methanol / 4 h / Heating 2: 86 percent / 0.1 N HCl / trifluoroacetic acid / 55 °C View Scheme
参考文献
Nair; Adapa; Bridges
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3152 - 3155
反应条件
1: 86 percent / 0.1 N HCl / trifluoroacetic acid / 55 °C View Scheme
参考文献
Nair; Adapa; Bridges
Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3152 - 3155
