1: With 1-methyl-piperazine; isobutyl chloroformate in N,N-dimethyl-formamide T=-40 - -20°C; 0.333333 h; 2: With ammonia in water; N,N-dimethyl-formamide 0.25 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/81195 A1, 2009 ;
Location in patent: Page/Page column 77 ;
WO 2009/081195 A1