2,3,4,5-四甲氧基甲苯合成路线 （共 45 条）
反应条件
1: 98 percent / TiCl4 / CH2Cl2 / 4 h / Ambient temperature
2: NaBH4 / ethanol / 0.5 h / 0 °C
3: PBr3 / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Ma, Wei; Li, Da-Wei; Sutherland, Todd C.; Li, Yang; Long, Yi-Tao; Chen, Hong-Yuan
Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12366 - 12369
反应条件
titanium tetrachloride in dichloromethane
4 h; Ambient temperature;
参考文献
Ohkawa, Shigenori; Terao, Shinji; Terashita, Zen-ichi; Shibouta, Yumiko; Nishikawa, Kohei
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 267 - 276
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in water; trifluoroacetic acid
参考文献
Nisshin Flour Milling Co., Ltd.
Patent: US5756475 A1, 1998 ;
US 5756475 A
反应条件
1: 78 percent / HCl / H2O / 40 °C
2: 84 percent / CAN / acetonitrile; H2O / 1 h / 0 °C
3: 1.) Cp2ZrCl2, 2.) NiCl2, PPh3, n-BuLi / 1.) ClCH2CH2Cl, 0 deg C, 2.) THF, hexane. -78 deg C, 30 min, -78 deg C to 0 deg C, 1.75 h
View Scheme
参考文献
Lipshutz, Bruce H.; Kim, Sung-Kyu; Mollard, Paul; Stevens, Kirk L.
Tetrahedron, 1998 , vol. 54, # 7 p. 1241 - 1253
反应条件
2: 84 percent / pyridine-2,6-dicarboxylate, ceric ammonium nitrate (CAN) / acetonitrile; H2O / a.) 20 min, 0 deg C b.) 10 min, RT
View Scheme
参考文献
Syper, L.; Kloc, K.; Mlochowski, J.
Tetrahedron, 1980 , vol. 36, # 1 p. 123 - 129
