FMOC-beta-丙氨酸合成路线 （共 10 条）
反应条件
sodium carbonate in 1,4-dioxane 1.) ice bath, 1 h, 2.) r.t., 3 h;
参考文献
Bain; Wacker, Dean A.; Kuo, Eric E.; Chamberlin, A. Richard
Tetrahedron, 1991 , vol. 47, # 14-15 p. 2389 - 2400
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 0.5 h;
参考文献
Antsypovich, Sergey I.; Oretskaya, Tatiana S.; Volkov, Evgeny M.; Romanova, Elena A.; Tashlitsky, Vadim N.; Blumenfeld, Marta; Shabarova, Zoe A.
Nucleosides and Nucleotides, 1996 , vol. 15, # 4 p. 923 - 936
反应条件
sodium carbonate in water; N,N-dimethyl-formamide T=20°C;
参考文献
Shu, Lianhe; Wang, Ping
Organic Process Research and Development, 2008 , vol. 12, # 2 p. 298 - 300
反应条件
hydrazine in N,N-dimethyl-formamide
参考文献
Tetrahedron, , vol. 58, # 27 p. 5427 - 5439
反应条件
1.1: Fmoc-Cl; N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C 1.2: 91 percent / tetrahydrofuran; diethyl ether / 0 - 20 °C 2.1: 78 percent / silver benzoate / dioxane; H2O / 0.02 h / microwave irradiation View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 43, # 10 p. 2152 - 2158
反应条件
1: oxalyl chloride; N,N-dimethylformamide / tetrahydrofuran / 2 h / 20 °C 2: 1.27 g / (Ph3P)4Pd; tributyltin hydride / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Evans, Christopher G.; Smith, Matthew C.; Carolan, James P.; Gestwicki, Jason E.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 9 p. 2587 - 2590
反应条件
triethylsilane 1.) TFA, CHCl3, H2O, 30 min, 2.) TFA, CHCl3, H2O; Yield given. Multistep reaction;
参考文献
Luke, Richard W. A.; Boyce, Patrick G. T.; Dorling, E. Kate
Tetrahedron Letters, 1996 , vol. 37, # 2 p. 263 - 266
反应条件
thionyl chloride in dichloromethane
T=50°C; 0.133333 h; Microwave irradiation;
参考文献
Sosic, Alice; Frecentese, Francesco; Perissutti, Elisa; Sinigaglia, Laura; Santagada, Vincenzo; Caliendo, Giuseppe; Magli, Elisa; Ciano, Antonio; Zagotto, Giuseppe; Parolin, Cristina; Gatto, Barbara
MedChemComm, 2013 , vol. 4, # 10 p. 1388 - 1393
参考文献
Grover, Rajesh K.; Kesarwani, Amit P.; Srivastava, Gaurav K.; Kundu, Bijoy; Roy, Raja
Tetrahedron, 2005 , vol. 61, # 21 p. 5011 - 5018
