1,1-二(4-氟苯基)-2-1-丙醇合成路线 （共 14 条）
反应条件
acetylene in benzene T=55°C; 4 h;
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: in tetrahydrofuran T=20°C; 24 h; Inert atmosphere; 2: With water; ammonium chloride in tetrahydrofuran; diethyl ether Saturated solution;
参考文献
Boettcher, Christoph; Zeyat, Gehad; Ahmed, Saleh A.; Irran, Elisabeth; Rueck-Braun, Karola; Cordes, Thorben; Elsner, Cord; Zinth, Wolfgang
Beilstein Journal of Organic Chemistry, 2009 , vol. 5, art. no. A25
反应条件
1: acetylene With ethylmagnesium bromide in tetrahydrofuran T=0 - 25°C; 1.16667 h; 2: 1,1-di(p-fluorophenyl)-ketone in tetrahydrofuran T=23 - 25°C; 5 h;
参考文献
Wang, Jia; Zhu, Hai-Tao; Li, Ying-Xiu; Wang, Li-Jing; Qiu, Yi-Feng; Qiu, Zi-Hang; Zhong, Mei-Jin; Liu, Xue-Yuan; Liang, Yong-Min
Organic Letters, 2014 , vol. 16, # 8 p. 2236 - 2239
反应条件
in tetrahydrofuran; xylene T=-5 - 20°C;
参考文献
Teral, Yannick; Roubaud, Gabriel; Aubert, Claude; Faure, Robert; Campredon, Mylene
Australian Journal of Chemistry, 2005 , vol. 58, # 7 p. 517 - 521
反应条件
1: With n-butyllithium in tetrahydrofuran 2: With potassium hydroxide in methanol
参考文献
Manuel Oliveira; Salvador, Maria A.; Vermeersch, Gaston; Berthet, Jerome; Delbaere, Stephanie
Molecular Crystals and Liquid Crystals, 2005 , vol. 431, p. 173/[473]-185/[485]
反应条件
in tetrahydrofuran T=20°C; 1 - 10 h;
参考文献
Mothe, Srinivasa Reddy; Lauw, Sherman Jun Liang; Kothandaraman, Prasath; Chan, Philip Wai Hong
Journal of Organic Chemistry, 2012 , vol. 77, # 16 p. 6937 - 6947
反应条件
ethanol; potassium carbonate in dichloromethane
参考文献
Dillard,R.D. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 6 p. 1155 - 1158
反应条件
(i) Py, CH2Cl2, (ii) /BRN= 471175/, Et2O; Multistep reaction;
参考文献
Dillard,R.D. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 40 - 44
反应条件
1: 61 percent / PPh3; H2 / HRh(CO)(PPh3)3 / toluene / 24 h / 100 °C / 76000 Torr 2: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C 3: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating 4: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C 5: 75 percent / Na2CO3; KI / toluene / Heating View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
反应条件
1: 61 percent / PPh3; H2 / HRh(CO)(PPh3)3 / toluene / 24 h / 100 °C / 76000 Torr 2: 90 percent / NaBH4; aq. NaOH / methanol / 3 h / 20 °C 3: 85 percent / H2 / 10 percent Pd/C / aq. ethanol / Heating 4: 80 percent / Br2; PPh3 / acetonitrile / 2 h / 20 °C 5: 70 percent / Na2CO3; KI / toluene / 66 h / Heating View Scheme
参考文献
Botteghi, Carlo; Marchetti, Mauro; Paganelli, Stefano; Persi-Paoli, Francesco
Tetrahedron, 2001 , vol. 57, # 8 p. 1631 - 1637
