4-(4-(4-(三氟甲基)苯基)噻唑-2-基)苯胺合成路线 （共 7 条）
反应条件
in acetone T=20°C; 24 h;
参考文献
UNIVERSITY HEALTH NETWORK; SAMPSON, Peter Brent; LIU, Yong; LI, Sze-Wan; FORREST, Bryan T.; PAULS, Heinz W.; EDWARDS, Louise G.; FEHER, Miklos; PATEL, Narendra Kumar B.; LAUFER, Radoslaw; PAN, Guohua
Patent: WO2011/123946 A1, 2011 ;
Location in patent: Page/Page column 98 ;
反应条件
in tetrahydrofuran T=20°C; 20 h;
参考文献
Suginome, Michinori; Yamamoto, Akihiko; Ito, Yoshihiko
Chemical Communications, 2002 , # 13 p. 1392 - 1393
反应条件
in neat (no solvent) T=60°C;
参考文献
Popov; Mokhov; Tankabekyan
Russian Journal of Organic Chemistry, 2014 , vol. 50, # 1 p. 21 - 24
Zh. Org. Khim., 2014 , vol. 50, # 1 p. 29 - 32,4
参考文献
Journal of the American Chemical Society, , vol. 79, p. 6230,6231
Journal of the American Chemical Society, , vol. 72, p. 2804
反应条件
tert-butyl magnesium halide
参考文献
Henze et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 6230,6231
参考文献
Maillard,J. et al.
Chimica Therapeutica, 1969 , vol. 4, p. 80 - 88
反应条件
potassium carbonate
T=80 - 100°C;
参考文献
Popov, Yu. V.; Mokhov; Tankabekyan
Russian Journal of Organic Chemistry, 2013 , vol. 49, # 8 p. 1135 - 1138
Zhurnal Organicheskoi Khimii, 2013 , vol. 49, # 8 p. 1153 - 1156,4
