S-甲基异硫氨基脲盐酸盐合成路线 （共 35 条）
反应条件
Amberlite IRA-401
1.) water, reflux, 3.5 h; Yield given. Multistep reaction;
参考文献
Nakashima, Kunio; Hibasami, Hiroshige; Tsukada, Tetsuya; Maekawa, Satoru
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 553 - 558
反应条件
(i) SeO2, H2O, dioxane, (ii) NaHCO3, (iii) /BRN= 3653342/; Multistep reaction;
参考文献
Trust,R.I. et al.
Journal of Heterocyclic Chemistry, 1979 , vol. 16, p. 1393 - 1403
反应条件
in ethanol; water
10 h; Heating;
参考文献
Heilman; Scozzie; Wayner; Gullo; Ariyan
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 3 p. 282 - 287
反应条件
sodium hydrogencarbonate in ethanol; water
2 h; Reflux; regioselective reaction;
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
sodium hydrogencarbonate in ethanol
T=0°C; 4 h;
参考文献
Taylor, C. Edward; Pont, Joseph L.; Warner, John C.
Tetrahedron, 1987 , vol. 43, # 21 p. 5159 - 5168
反应条件
in ethanol; water
10 h; Heating;
参考文献
Heilman; Scozzie; Wayner; Gullo; Ariyan
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 3 p. 282 - 287
反应条件
in ethanol; water
10 h; Heating;
参考文献
Heilman; Scozzie; Wayner; Gullo; Ariyan
Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 3 p. 282 - 287
反应条件
triethylamine in ethanol
1 h; Heating;
参考文献
Neunhoeffer, Hans; Hammann, Heinz
Liebigs Annalen der Chemie, 1984 , # 2 p. 283 - 295
反应条件
1: With sodium hydrogencarbonate in ethanol; water
T=0 - 20°C;
2: With 3-chloro-benzenecarboperoxoic acid in dichloromethane
T=0 - 20°C; 2.5 h; Further stages.;
参考文献
Carroll, F. Ivy; Kotturi, Sharadsrikar V.; Navarro, Hernan A.; Mascarella, S. Wayne; Gilmour, Brian P.; Smith, Forrest L.; Gabra, Bichoy H.; Dewey, William L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 14 p. 3388 - 3391
反应条件
sodium hydrogencarbonate
参考文献
Huang, Jim J.
Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2293 - 2298
