2,2',4,4'-四甲氧基二苯甲酮合成路线 （共 21 条）
反应条件
sodium methylate; tris(dibenzylideneacetone)dipalladium (0) in chloroform T=20°C; P=760 Torr; 3 h;
参考文献
Kang; Ryu; Choi
Synthetic Communications, 2001 , vol. 31, # 7 p. 1035 - 1039
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
Silvestri, Maximilian A.; Nagarajan, Muthukaman; De Clercq, Erik; Pannecouque, Christophe; Cushman, Mark
Journal of Medicinal Chemistry, 2004 , vol. 47, # 12 p. 3149 - 3162
反应条件
1: bromodifluoromethyl phenyl sulphide With titanium tetrachloride in dichloromethane T=20°C; Friedel Crafts type alkylation; 0.25 h; Inert atmosphere; 2: 1,3-dimethoxy benzene in dichloromethane T=20°C; Friedel Crafts type alkylation; 1 h; Inert atmosphere;
参考文献
Kuhakarn, Chutima; Surapanich, Nakin; Kamtonwong, Siriporn; Pohmakotr, Manat; Reutrakul, Vichai
European Journal of Organic Chemistry, 2011 , # 29 p. 5911 - 5918
反应条件
18-crown-6 ether; potassium carbonate in acetonitrile 20 h; Heating;
参考文献
Hecht; Frechet
Journal of the American Chemical Society, 2001 , vol. 123, # 28 p. 6959 - 6960
反应条件
potassium carbonate in acetone
参考文献
Corning S.A.
Patent: EP1038870 A1, 2000 ;
反应条件
1: bromodifluoromethyl phenyl sulphide With AlCl3, aluminium chloride in dichloromethane T=20°C; Friedel Crafts type alkylation; 0.25 h; Inert atmosphere; 2: 1,3-dimethoxy benzene in dichloromethane T=20°C; Friedel Crafts type alkylation; 16 h; Inert atmosphere;
参考文献
Kuhakarn, Chutima; Surapanich, Nakin; Kamtonwong, Siriporn; Pohmakotr, Manat; Reutrakul, Vichai
European Journal of Organic Chemistry, 2011 , # 29 p. 5911 - 5918
反应条件
1: 1-bromo-2,4-dimethoxy-benzene With n-butyllithium in diethyl ether T=-70°C; 2: N,N-Dimethylcarbamidsaeureethylester in diethyl ether T=-78 - -20°C;
参考文献
Abusalim, Deyaa I.; Merfeld, Michelle L.; Lash, Timothy D.
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10360 - 10368
反应条件
1: bromodifluoromethyl phenyl sulphide; 1,3-dimethoxy benzene With titanium tetrachloride in dichloromethane T=20°C; Friedel Crafts type alkylation; 1 h; Inert atmosphere; 2: 1,2,4-trimethoxy benzene in dichloromethane T=20°C; Friedel Crafts type alkylation; 6 h; Inert atmosphere;
参考文献
Kuhakarn, Chutima; Surapanich, Nakin; Kamtonwong, Siriporn; Pohmakotr, Manat; Reutrakul, Vichai
European Journal of Organic Chemistry, 2011 , # 29 p. 5911 - 5918
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere 1.2: 3 h / -60 °C / Inert atmosphere 2.1: titanium tetrachloride / dichloromethane / 0.25 h / 20 °C / Inert atmosphere 2.2: 1 h / 20 °C / Inert atmosphere View Scheme
参考文献
Kuhakarn, Chutima; Surapanich, Nakin; Kamtonwong, Siriporn; Pohmakotr, Manat; Reutrakul, Vichai
European Journal of Organic Chemistry, 2011 , # 29 p. 5911 - 5918
反应条件
1.1: N-bromosuccinmide 2.1: n-butyllithium / diethyl ether / -70 °C 2.2: -78 - -20 °C View Scheme
参考文献
Abusalim, Deyaa I.; Merfeld, Michelle L.; Lash, Timothy D.
Journal of Organic Chemistry, 2013 , vol. 78, # 20 p. 10360 - 10368
