1-(4-甲基苯基)-1H-吡咯-2-甲腈合成路线 （共 6 条）
反应条件
in methanol T=25°C; Electrolysis;
参考文献
Liu, Wei; Ma, Yuan; Yin, Ying-Wu; Zhao, Yu-Fen
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 681 - 684
反应条件
hydroxylamine hydrochloride; acetic anhydride; sodium carbonate 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h; Yield given. Multistep reaction;
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5389641 A1, 1995 ;
US 5389641 A
反应条件
1: POCl3 / 3 h / 110 - 120 °C 2: 1.) H2NOH*HCl/Na2CO3, 2.) Ac2O / 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h View Scheme
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
反应条件
1: 74 percent / CH3COOH / 2 h / Heating 2: POCl3 / 3 h / 110 - 120 °C 3: 1.) H2NOH*HCl/Na2CO3, 2.) Ac2O / 1.) MeOH, H2O, reflux, 3 h, 2.) reflux, 3 h View Scheme
参考文献
Ankersen, Michael; Peschke, Bernd; Hansen, Birgit Sehested; Hansen, Thomas Kruse
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 10 p. 1293 - 1298
反应条件
hydroxylamine hydrochloride; acetic anhydride; trichlorophosphate Multistep reaction;
参考文献
Ankersen, Michael; Peschke, Bernd; Hansen, Birgit Sehested; Hansen, Thomas Kruse
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 10 p. 1293 - 1298
反应条件
1: KOH / ethane-1,2-diol / 4 h / 167 °C 2: SOCl2 / 4 h / 25 °C 3: 16 h / 25 °C 4: 2.5 g / N-bromosuccinimide, 2,2'-azobisisobutyronitrile / CCl4 / 19 h / Heating View Scheme
参考文献
Bovy; Reitz; Collins; Chamberlain; Olins; Corpus; McMahon; Palomo; Koepke; Smits; McGraw; Gaw
Journal of Medicinal Chemistry, 1993 , vol. 36, # 1 p. 101 - 110
