2-溴-5-甲氧基苯甲酸甲酯合成路线 （共 29 条）
反应条件
thionyl chloride T=40°C; Esterification; 18 h;
参考文献
Ozaki, Shigeko; Adachi, Masashi; Sekiya, Sayaka; Kamikawa, Rie
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4586 - 4589
反应条件
1: With palladium 10 on activated carbon in methanol Inert atmosphere; 2: With hydrogen T=23°C;
参考文献
Rose, Nathan R.; Ng, Stanley S.; Mecinovic, Jasmin; Lienard, Benoit M. R.; Bello, Simon H.; Sun, Zhe; McDonough, Michael A.; Oppermann, Udo; Schofield, Christopher J.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7053 - 7056
参考文献
Yakugaku Zasshi, , vol. 76, p. 1122,1125
Chem.Abstr., , p. 3505
反应条件
copper quinolate in water; dimethyl sulfoxide T=120°C; 24 h;
参考文献
Zhu, Yan; Yan, Hong; Lu, Linhua; Liu, Defu; Rong, Guangwei; Mao, Jincheng
Journal of Organic Chemistry, 2013 , vol. 78, # 19 p. 9898 - 9905
反应条件
tert.-butylhydroperoxide; hydrogen bromide in methanol 6 h; Heating;
参考文献
Barhate, Nivrutti B.; Gajare, Anil S.; Wakharkar, Radhika D.; Bedekar, Ashutosh V.
Tetrahedron, 1999 , vol. 55, # 36 p. 11127 - 11142
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile Reflux;
参考文献
Shen, Zhongqi; Siva Ramamoorthy; Hatzenbuhler, Nicole T.; Evrard, Deborah A.; Childers, Wayne; Harrison, Boyd L.; Chlenov, Michael; Hornby, Geoffrey; Smith, Deborah L.; Sullivan, Kelly M.; Schechter, Lee E.; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 222 - 227
反应条件
1: (i) Cu, (ii) aq. NaOH, MeOH 2: polyphosphoric acid 3: aq. HBr / acetic acid View Scheme
参考文献
Horner,L.; Baston,D.W.
Justus Liebigs Annalen der Chemie, 1973 , p. 910 - 935
反应条件
1: sodium carbonate / tris(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxy-ethane; H2O / 85 °C 2: sodium hydroxide / ethanol / 78 °C View Scheme
参考文献
Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611
反应条件
tetrabutyl-ammonium chloride; palladium diacetate; potassium carbonate; triphenylphosphine in N,N-dimethyl-formamide T=110°C; 2 h;
参考文献
Tetrahedron Letters, , vol. 49, # 46 p. 6569 - 6572
反应条件
sodium carbonate; palladium diacetate in isobutyramide T=110°C; 36 h; Product distribution / selectivity;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/20306 A2, 2008 ;
Location in patent: Page/Page column 26-27 ;
