[1-甲基-2-(4’-丁酸乙酯基)-5-N, N-二(2’-羟基乙基)]-1H -苯并咪唑合成路线 (共 15 条)
反应条件
1: With NaOAc·3H2O in water; acetic acid T=0 - 25°C; 23 h; 2: With potassium carbonate in dichloromethane T=20 - 25°C;
参考文献
FRESENIUS KABI ONCOLOGY LIMITED; MISHRA, Bhuwan Bhaskar; KACHHADIA, Nikunj Shambhubhai; TOMAR, Vinod Singh; LAHIRI, Saswata
Patent: US2014/121383 A1, 2014 ;
Location in patent: Paragraph 0094 ;
反应条件
calcium carbonate in acetonitrile T=80 - 90°C;
参考文献
FRESENIUS KABI ONCOLOGY LIMITED; MISHRA, Bhuwan Bhaskar; KACHHADIA, Nikunj Shambhubhai; TOMAR, Vinod Singh; LAHIRI, Saswata
Patent: US2014/121383 A1, 2014 ;
Location in patent: Paragraph 0086; 0087 ;
反应条件
sodium acetate; acetic acid in water T=0 - 25°C; 23 h; ConcentrationTemperatureTimeReagent/catalystSolvent;
参考文献
FRESENIUS KABI ONCOLOGY LTD.; MISHRA, Bhuwan Bhaskar; KACHHADIA, Nikunj Shambhubhai; TOMAR, Vinod Singh; LAHIRI, Saswata
Patent: WO2013/46223 A1, 2013 ;
Location in patent: Page/Page column 24 ;
反应条件
hydrogenchloride in water T=60°C; pH=Ca. 2; 2.5 h;
参考文献
WO2013/150020 A1, ;
Page/Page column 17 ;
反应条件
acetic acid in water T=0 - 20°C; 31 h;
参考文献
Hetero Research Foundation; Reddy, Bandi Parthasaradhi; Reedy, Kura Rathnakar; Reddy, Dasari Muralidhara; Krishna, Bandi Vamsi
Patent: US2014/121384 A1, 2014 ;
Location in patent: Paragraph 0041 ;
反应条件
((NH4)2HPO4) in water T=65 - 70°C; pH=4.2 - 5.5;
参考文献
EP2690096 A1, ;
Paragraph 0079; 0080 ;
反应条件
sodium carbonate; sodium iodide T=20 - 70°C;
参考文献
WO2012/7966 A2, ;
Page/Page column 4-5 ;
反应条件
1: hydrogenchloride; ammonium chloride / iron / water; methanol / 2 h / 60 - 65 °C 2: sodium iodide; sodium carbonate / 20 - 70 °C View Scheme
反应条件
1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / |Reflux 4.1: iron sulphate heptahydrate; hydrogen; Iron (III) nitrate nonahydrate; 5 Pd/C / ethanol / 3000.3 Torr 5.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / |Large scale View Scheme
反应条件
1.1: toluene / 4 h / 70 - 85 °C 2.1: water / 3 h / 75 °C 2.2: 55 - 60 °C 3.1: sulfuric acid / 10 h / |Reflux 4.1: iron sulphate heptahydrate; hydrogen; Iron (III) nitrate nonahydrate; 5 Pd/C / ethanol / 3000.3 Torr 5.1: potassium carbonate / water / 13.5 h / 69 - 70 °C / pH 4.2 - 5.5 / |Large scale View Scheme