1-甲基-5-硝基-1H-苯并咪唑-2-丁酸乙酯合成路线 （共 7 条）
反应条件
sulfuric acid 10 h; Reflux;
参考文献
Heyl Chemisch-pharmazeutische Fabrik GmbH and Co. KG; Frey, Michael; Walther, Dirk-Detlef
Patent: US2014/31560 A1, 2014 ;
Location in patent: Paragraph 0101; 0102 ;
反应条件
1.1: hydrogenchloride / toluene / 4 h / 85 °C 1.2: 3 h / 75 °C 2.1: sulfuric acid / 10 h / |Reflux View Scheme
反应条件
1.1: hydrogenchloride / toluene / 4 h / 85 °C 1.2: 3 h / 75 °C 2.1: sulfuric acid / 10 h / |Reflux View Scheme
反应条件
1: hydrogenchloride; ammonium chloride / iron / water; methanol / 2 h / 60 - 65 °C 2: sodium iodide; sodium carbonate / 20 - 70 °C View Scheme
参考文献
HEYL Chemisch-Pharmazeutische Fabrik GmbH und Co. KG; Frey, Michael; Walther, Dirk-Detlef
Patent: EP2690096 A1, 2014 ;
反应条件
1.1: iron; hydrogenchloride; ammonium chloride / methanol; water / 2 h / 60 - 65 °C 2.1: sodium carbonate; sodium iodide / 65 - 70 °C 3.1: thionyl chloride / dichloromethane / 0 °C / |Reflux 3.2: 80 - 90 °C View Scheme
反应条件
5 Pd/C-iron; hydrogen in ethanol P=3000.3 Torr;
参考文献
US2014/31560 A1, ;
Paragraph 0103; 0104; 0105; 0106 ;
反应条件
1: 5 Pd/C-iron; hydrogen / ethanol / 3000.3 Torr 2: potassium iodide; DAHP / water / 65 - 70 °C / pH 4.2 - 5.5 3: thionyl chloride / dichloromethane / 16 h / 5 - 20 °C View Scheme
