3-氯甲基-5-甲基异恶唑合成路线 （共 10 条）
反应条件
thionyl chloride in dichloromethane T=20°C; 1.33333 h; Heating / reflux;
参考文献
Hogenkamp, Derk J.; Johnstone, Timothy B.C.; Gee, Kelvin W.
Patent: US2006/293329 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
1: NaOH 2: SOCl2 3: Et3N / toluene / Ambient temperature View Scheme
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
反应条件
ethanol Erwaermen der Reaktionsloesung mit wss. HCl;
参考文献
Stagno d'Alcontres; Cuzzocrea
Atti della Societa Peloritana di Scienze Fisiche, Matematiche e Naturali, 1957 , vol. 3, p. 179,185
反应条件
N-benzyl-N,N,N-triethylammonium chloride in dichloromethane; water 16 h; Heating / reflux;
参考文献
Hogenkamp, Derk J.; Johnstone, Timothy B.C.; Gee, Kelvin W.
Patent: US2006/293329 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
in dimethyl sulfoxide T=20°C; 16 h;
参考文献
CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; TAYLOR, Alexander, M.; VASWANI, Rishi, G.
Patent: WO2013/184878 A1, 2013 ;
Location in patent: Paragraph 00194; 00195 ;
反应条件
sodium hydride
1.) benzene, 1 h, 2.) benzene, a.) RT, 4 h, b.) reflux, 4 h; Yield given. Multistep reaction;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
参考文献
Beecham Group p.l.c.
Patent: US4812470 A1, 1989 ;
反应条件
1: 1.) Na / 1.) EtOH, 20 deg C, 1 h, 2.) EtOH, reflux, 2 h
2: 1.) aq. NaOH / dioxane
View Scheme
参考文献
Sokolov, S. D.; Vinogradova, S. M.; Berg, M. V.; Mashkovskii, M. D.; Yuzhakov, S. D.; Ermakova, V. N.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 1 p. 30 - 36
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 1 p. 48 - 54
反应条件
1: dimethyl sulfoxide / 20 °C
2: potassium hydroxide / 1,4-dioxane
View Scheme
参考文献
CENTRAX INTERNATIONAL, INC.; FAN, Xiaoqing, Michelle; CEN, Jian, James
Patent: WO2014/18807 A1, 2014 ;
参考文献
Lepage; Tombret; Cuvier; Marivain; Gillardin
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 6 p. 581 - 593
