[3-(三氟甲基)苯氧基]乙酸合成路线 （共 9 条）
反应条件
1: With sodium hydroxide; water in methanol T=20°C; 0.333333 h; 2: With hydrogenchloride in water
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/78291 A1, 2008 ;
Location in patent: Page/Page column 57 ;
WO 2008/078291 A1
反应条件
potassium hydroxide in water 1 h; Heating;
参考文献
Tetrahedron, , vol. 60, # 52 p. 12231 - 12237
反应条件
sodium hydroxide; water T=100°C;
参考文献
Journal of the American Chemical Society, , vol. 70, p. 2849,2851
Journal of the American Chemical Society, , vol. 69, p. 718,721
反应条件
potassium carbonate in dimethyl sulfoxide T=70 - 80°C; 5 h;
参考文献
Chen, Ting; Shen, Ping; Li, Yanjun; He, Hongwu
Phosphorus, Sulfur and Silicon and the Related Elements, 2006 , vol. 181, # 9 p. 2135 - 2145
反应条件
1: potassium carbonate / dimethylsulfoxide / 5 h / 70 - 80 °C 2: NaOH / acetone / 2 h / 20 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 127, # 2 p. 291 - 295
反应条件
(i) K2CO3, DMF, (ii) TsOH, toluene; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 15, # 9 p. 940 - 944
参考文献
Metz; Specker
Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 11 p. 1686 - 1692
参考文献
Chen, Ting; Shen, Ping; Li, Yanjun; He, Hongwu
Phosphorus, Sulfur and Silicon and the Related Elements, 2006 , vol. 181, # 9 p. 2135 - 2145
Title/Abstract Full Text View citing articles Show Details
Chen, Ting; Shen, Ping; Li, Yanjun; He, Hongwu
Journal of Fluorine Chemistry, 2006 , vol. 127, # 2 p. 291 - 295
参考文献
Soper et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 2849,2851
