4-溴-3-硝基三氟甲苯合成路线 （共 12 条）
反应条件
copper(I) bromide; lithium bromide in tetrahydrofuran T=160°C; 6 h; Product distribution / selectivity;
参考文献
Bayer CropScience S.A.
Patent: US6635780 B1, 2003 ;
Location in patent: Page/Page column 12 ;
参考文献
van der Stelt,C. et al.
Arzneimittel Forschung, 1964 , vol. 14, p. 964 - 967
反应条件
1: SnCl2 2: (deamination) View Scheme
参考文献
van der Stelt,C. et al.
Arzneimittel Forschung, 1964 , vol. 14, p. 964 - 967
反应条件
lithium bromide in acetonitrile T=110°C; 18 h; Product distribution / selectivity;
参考文献
Bayer CropScience S.A.
Patent: US6635780 B1, 2003 ;
Location in patent: Page/Page column 10 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=130°C; 4 h;
参考文献
DILLARD, Lawrence W.; YUAN, Jing; LEFTHERIS, Katerina; VENKATRAMAN, Shankar; WU, Guosheng; JIA, Lanqi; XU, Zhenrong; CACATIAN, Salvacion; MORALES-RAMOS, Angel; SINGH, Suresh; ZHENG, Yajun
Patent: WO2011/106414 A1, 2011 ;
Location in patent: Page/Page column 74 ;
WO 2011/106414 A1
反应条件
T=130°C; 6 h; Product distribution / selectivity;
参考文献
Bayer CropScience S.A.
Patent: US6635780 B1, 2003 ;
Location in patent: Page/Page column 9-10 ;
反应条件
potassium carbonate in butan-1-ol 5.5 h; Heating;
参考文献
Li, Wen-Shan; Zhang, Nanjing; Sayre, Lawrence M.
Tetrahedron, 2001 , vol. 57, # 21 p. 4507 - 4522
反应条件
1: 89 percent / bis(triphenylphosphine)palladium(II) chloride / triethylamine / 75 °C 2: 1.) KOH, 2.) acetic acid / 1.) 20 min, reflux 3: 99 percent / H2 / Pd/C / methanol; acetic acid / Ambient temperature 4: 95 percent / HCl / aq. HCl; ethanol / 0.5 h / 60 °C View Scheme
参考文献
Tischler, Allan N.; Lanza, Thomas J.
Tetrahedron Letters, 1986 , vol. 27, # 15 p. 1653 - 1656
反应条件
copper(l) iodide; (1S,2S)-1,2-diaminocyclohexane in water T=120°C;
参考文献
Carril, Monica; SanMartin, Raul; Dominguez, Esther; Tellitu, Imanol
Chemistry - A European Journal, 2007 , vol. 13, # 18 p. 5100 - 5105
反应条件
triethylamine; palladium on carbon catalyst T=100°C; P=2585.81 - 3878.71 Torr; 13 h;
参考文献
Eastman Chemical Co.
Patent: US6337418 B1, 2002 ;
Location in patent: Example 3 ;
