反应条件
1: 3-methoxyacrylic acid methyl ester With N-bromosuccinmide in 1,4-dioxane; water; ethyl acetate T=0°C; 1 h; 2: thiourea in 1,4-dioxane; water T=80°C; 2 h;
参考文献
Stachulski, Andrew V.; Pidathala, Chandrakala; Row, Eleanor C.; Sharma, Raman; Berry, Neil G.; Iqbal, Mazhar; Bentley, Joanne; Allman, Sarah A.; Edwards, Geoffrey; Helm, Alison; Hellier, Jennifer; Korba, Brent E.; Semple, J. Edward; Rossignol, Jean-Francois
Journal of Medicinal Chemistry, 2011 , vol. 54, # 12 p. 4119 - 4132