5-氟吲哚-2-甲酸乙酯合成路线 （共 26 条）
反应条件
thionyl chloride in ethanol 3 h; Reflux;
参考文献
Bruel, Amelie; Loge, Cedric; Tauzia, Marie-Ludivine De; Ravache, Myriam; Le Guevel, Remy; Guillouzo, Christiane; Lohier, Jean-Francois; Oliveira Santos, Jana Sopkova-De; Lozach, Olivier; Meijer, Laurent; Ruchaud, Sandrine; Benedetti, Helene; Robert, Jean-Michel
European Journal of Medicinal Chemistry, 2012 , vol. 57, p. 225 - 233
反应条件
zinc(II) chloride T=220°C;
参考文献
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 297, p. 229,233
反应条件
copper(I) oxide; caesium carbonate in 1-methyl-pyrrolidin-2-one T=100°C; 16 h; Inert atmosphereSealed tube;
参考文献
Zhu, Zhiqiang; Yuan, Jiangjun; Zhou, Yirong; Qin, Yang; Xu, Jingshi; Peng, Yiyuan
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 511 - 514
反应条件
copper(l) iodide; caesium carbonate in dimethyl sulfoxide T=80°C; 16 h; Inert atmosphere;
参考文献
Koenig, Stefan G.; Dankwardt, John W.; Liu, Yanbing; Zhao, Hang; Singh, Surendra P.
Tetrahedron Letters, 2010 , vol. 51, # 50 p. 6549 - 6551
反应条件
tetrabutylammomium bromide; palladium diacetate; sodium hydrogencarbonate in acetonitrile T=80°C; Heck-Jeffery amination; 96 h; Inert atmosphere;
参考文献
McNulty, James; Keskar, Kunal
European Journal of Organic Chemistry, 2011 , # 34 p. 6902 - 6908
反应条件
Bi(NO3)3; PPA in methanol 2 h; Reflux;
参考文献
Sudhakara; Jayadevappa; Mahadevan; Hulikal, Vijaykumar
Synthetic Communications, 2009 , vol. 39, # 14 p. 2506 - 2515
反应条件
thionyl chloride 3 h; RefluxCooling;
参考文献
Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 24 p. 8206 - 8220
反应条件
1.1: hydrogenchloride / water / 2 h / 20 °C 1.2: 1 h / 5 °C 2.1: acetic acid / ethanol / Reflux 3.1: polyphosphoric acid / 4 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3149 - 3157
反应条件
1: acetic acid / ethanol / 1 h / 80 °C 2: polyphosphoric acid / toluene / 5 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 125 - 138
反应条件
1: acetic acid / ethanol / Reflux 2: polyphosphoric acid / 4 h / 100 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 7 p. 3149 - 3157
