1-甲基-4-哌啶酮盐酸盐合成路线 （共 11 条）
反应条件
1: With ammonium acetate in methanol 0.166667 h; 2: With sodium cyanoborohydride in methanol 1 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: EP1229035 A1, 2002 ;
Location in patent: Page 33 ;
Title/Abstract Full Text Show Details
SMITHKLINE BEECHAM CORPORATION
Patent: EP1227091 A2, 2002 ;
Location in patent: Page 33 ;
参考文献
Lyle; Lyle
Journal of the American Chemical Society, 1954 , vol. 76, p. 3536,3538
反应条件
in water T=0°C; 3 h;
参考文献
Swain; Baker; Kneen; Herbert; Moseley; Saunders; Seward; Stevenson; Beer; Stanton; Watling; Ball
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1019 - 1031
反应条件
in ethanol T=80°C; 16 h;
参考文献
MEDIVATION TECHNOLOGIES, INC.
Patent: WO2009/55828 A1, 2009 ;
Location in patent: Page/Page column 250 ;
WO 2009/055828 A1
反应条件
isopropyl alcohol 22 h; HeatingIrradiationPRK-2 mercury-quartz lamp;
参考文献
Kostochka, L. M.; Belostotskii, A. M.; Skoldinov, A. P.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 2315 - 2316
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 12 p. 2623 - 2624
反应条件
1: TsOH / benzene 2: benzene / Heating 3: KOH / ethanol / Heating View Scheme
参考文献
, vol. 38, # 12 p. 3879 - 3901
反应条件
1: H2O
2: concentrated aqueous HCl. / Erwaermen des Reaktionsprodukts mit aethanol. H2SO4
3: diethyl ether
4: concentrated sulfuric acid / 0 °C
View Scheme
参考文献
Lyle; Lyle
Journal of the American Chemical Society, 1954 , vol. 76, p. 3536,3538
参考文献
Boekelheide; Ainsworth
Journal of the American Chemical Society, 1950 , vol. 72, p. 2134,2137
参考文献
Sapi; Grebille; Laronze; Levy
Synthesis, 1992 , # 4 p. 383 - 386
反应条件
1: TsOH / benzene
2: benzene / Heating
View Scheme
参考文献
Sindelar; Rajsner; Cervena; et al.
1973 , vol. 38, # 12 p. 3879 - 3901
