6-溴-2-叔丁氧羰基氨基吡啶合成路线 （共 7 条）
反应条件
triethylamine in dichloromethane T=20°C; 72 h; Product distribution / selectivity;
参考文献
NOVARTIS AG; ANTONIOS-MCCREA, William R.; BARSANTI, Paul A.; HU, Cheng; JIN, Xianming; LIN, Xiaodong; MARTIN, Eric J.; PAN, Yue; PFISTER, Keith B.; RENHOWE, Paul A.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng
Patent: WO2012/101066 A1, 2012 ;
Location in patent: Page/Page column 77 ;
WO 2012/101066 A1
反应条件
diphenylphosphoranyl azide; triethylamine 2 h; Heating / reflux;
参考文献
PFIZER INC.
Patent: WO2006/43145 A1, 2006 ;
Location in patent: Page/Page column 104 ;
WO 2006/043145 A1
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate T=-15 - -5°C; 2.8 h;
参考文献
US2013/5981 A1, ;
Page/Page column 6 ;
反应条件
4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C;
参考文献
US2011/92537 A1, ;
Page/Page column 29-30 ;
反应条件
1: With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=0°C; 2: With ammonium chloride in tetrahydrofuran; water Purification / work up;
参考文献
WO2009/115557 A2, ;
Page/Page column 100-101 ;
反应条件
hydrogen bromide 2 h; Ambient temperature;
参考文献
Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E.
Australian Journal of Chemistry, 1982 , vol. 35, # 10 p. 2025 - 2034
反应条件
1: 25percent HBr / 2 h / Ambient temperature
2: concd. H2SO4, fuming HNO3 / 0.33 h / 0 °C
View Scheme
参考文献
Deady, Leslie W.; Korytsky, Olga L.; Rowe, Jeffrey E.
Australian Journal of Chemistry, 1982 , vol. 35, # 10 p. 2025 - 2034
