6-氟-2-(4-硝基苯基)苯并噻唑合成路线 （共 8 条）
反应条件
Na2S2O5 in dimethyl sulfoxide T=120°C;
参考文献
Weekes, Ashley A.; Bagley, Mark C.; Westwell, Andrew D.
Tetrahedron, 2011 , vol. 67, # 40 p. 7743 - 7747
反应条件
sodium hydroxide; potassium hexacyanoferrate(III) in ethanol; water T=90°C; 0.5 h;
参考文献
Kamal, Ahmed; Reddy, K. Srinivasa; Khan, M. Naseer A.; Shetti, Rajesh V.C.R.N.C.; Ramaiah, M. Janaki; Pushpavalli; Srinivas, Chatla; Pal-Bhadra, Manika; Chourasia, Mukesh; Sastry, G. Narahari; Juvekar, Aarti; Zingde, Surekha; Barkume, Madan
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 13 p. 4747 - 4761
反应条件
in dimethyl sulfoxide T=180°C; 0.5 h;
参考文献
SNU RandDB FOUNDATION
Patent: US2011/250136 A1, 2011 ;
反应条件
1: 80 percent / Lawesson's reagent; HMPA / 15 h / 100 °C 2: 52 percent / aq. NaOH; K3Fe(CN)6 / ethanol / 2 h / 90 °C View Scheme
参考文献
Kamal, Ahmed; Faazil, Shaikh; Ramaiah, M. Janaki; Ashraf, Md.; Balakrishna; Pushpavalli; Patel, Nibedita; Pal-Bhadra, Manika
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5733 - 5739
反应条件
1: 88 percent / pyridine / 1 h / Heating 2: 80 percent / Lawesson's reagent; HMPA / 15 h / 100 °C 3: 52 percent / aq. NaOH; K3Fe(CN)6 / ethanol / 2 h / 90 °C View Scheme
参考文献
Kamal, Ahmed; Faazil, Shaikh; Ramaiah, M. Janaki; Ashraf, Md.; Balakrishna; Pushpavalli; Patel, Nibedita; Pal-Bhadra, Manika
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5733 - 5739
反应条件
1: 88 percent / pyridine / 1 h / Heating 2: 80 percent / Lawesson's reagent; HMPA / 15 h / 100 °C 3: 52 percent / aq. NaOH; K3Fe(CN)6 / ethanol / 2 h / 90 °C View Scheme
参考文献
Kamal, Ahmed; Faazil, Shaikh; Ramaiah, M. Janaki; Ashraf, Md.; Balakrishna; Pushpavalli; Patel, Nibedita; Pal-Bhadra, Manika
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 20 p. 5733 - 5739
反应条件
in N,N-dimethyl-formamide T=140°C; 18 h;
参考文献
Pan, Jinhe; Mason, Neale S.; Debnath, Manik L.; Mathis, Chester A.; Klunk, William E.; Lin, Kuo-Shyan
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1720 - 1726
反应条件
1: With SnCl2·2H2O in methanol 5 h; Reflux; 2: With sodium hydrogencarbonate
参考文献
Kamal, Ahmed; Reddy, K. Srinivasa; Khan, M. Naseer A.; Shetti, Rajesh V.C.R.N.C.; Ramaiah, M. Janaki; Pushpavalli; Srinivas, Chatla; Pal-Bhadra, Manika; Chourasia, Mukesh; Sastry, G. Narahari; Juvekar, Aarti; Zingde, Surekha; Barkume, Madan
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 13 p. 4747 - 4761
