2,5-二溴-3-甲基吡啶合成路线 （共 18 条）
反应条件
1: N,N-dimethyl-formamide / 12 h / 120 °C 2: water; sodium hydroxide / ethanol / 1.5 h / 80 °C 3: potassium carbonate / N,N-dimethyl-formamide / 0.67 h / 80 °C View Scheme
参考文献
Incyte Corporation; Huang, Taisheng; Feng, Hao; Kong, Lingquan; Wang, Anlai; Ye, Hai Fen
Patent: US2013/96144 A1, 2013 ;
反应条件
in N,N-dimethyl-formamide 2 h; Reflux;
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
Location in patent: Paragraph 0176 ;
反应条件
in N,N-dimethyl-formamide T=120°C; 12 h;
参考文献
ASTRAZENECA AB
Patent: WO2008/100715 A1, 2008 ;
Location in patent: Page/Page column 33 ;
WO 2008/100715 A1
反应条件
potassium tert-butylate
T=80°C; 39 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/109907 A1, 2009 ;
Location in patent: Page/Page column 45 ;
WO 2009/109907 A1
反应条件
1: 2,5-dibromo-3-methylpyridine With isopropylmagnesium chloride in tetrahydrofuran
T=0 - 25°C; 3 h;
2: (4-morpholinyl)methanone in tetrahydrofuran
T=17 - 25°C; 1 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/71956 A1, 2007 ;
Location in patent: Page/Page column description ;
WO 2007/071956 A1
反应条件
1: 2,5-dibromo-3-methylpyridine With isopropylmagnesium chloride in tetrahydrofuran
T=0 - 25°C; 2 h;
2: carbon dioxide in tetrahydrofuran; diethyl ether
18 h;
3: With hydrogenchloride; water
pH=4;
参考文献
ASTRAZENECA AB
Patent: US2008/119451 A1, 2008 ;
Location in patent: Page/Page column 37 ;
US 20080119451 A1
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
4 h; Heatingirradiation;
参考文献
Kessar; Singh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 11 p. 1129 - 1131
反应条件
1.1: N-bromosuccinimide; dibenzoyl peroxide / CCl4 / 4 h / Heating; irradiation
2.1: 34.5 percent / ethanol / 20 °C
3.1: Na / Heating
3.2: 52 percent / 1.5 h / 140 °C
4.1: 70 percent / NaNH2; NH3 / diethyl ether / 1.5 h
5.1: 76.5 percent / MnO2 / CHCl3 / 1 h
View Scheme
参考文献
Kessar; Singh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001 , vol. 40, # 11 p. 1129 - 1131
