N-[(3-氯苯基)亚甲基]羟胺合成路线 （共 33 条）
反应条件
o-nitrobenzeneseleninic acid; dihydrogen peroxide T=20°C; 96 h;
参考文献
Said; Skarzewski; Mlochowski
Synthetic Communications, 1992 , vol. 22, # 13 p. 1851 - 1862
反应条件
N-chloro-succinimide in chloroform T=20°C; 0.333333 h;
参考文献
Rodrigues, Giseli Capaci; Feijo, Daniel Ferreira; Bozza, Marcelo Torres; Pan, Peiwen; Vullo, Daniela; Parkkila, Seppo; Supuran, Claudiu T.; Capasso, Clemente; Aguiar, Alcino Palermo; Vermelho, Alane Beatriz
Journal of Medicinal Chemistry, 2014 , vol. 57, # 2 p. 298 - 308
反应条件
1: thiophosphoryl trichloride; water; triethylamine / Neat (no solvent) 2: thiophosphoryl trichloride; water; triethylamine / Neat (no solvent) 3: water / 3.5 h / 85 - 90 °C / Neat (no solvent) View Scheme
参考文献
Synthesis, , vol. 44, # 3 art. no. H102311SS, p. 377 - 379
反应条件
1: sodium-amalgam; acetic acid
View Scheme
参考文献
Shoppee
Journal of the Chemical Society, 1932 , p. 696,703
反应条件
1: 3-chloro-benzaldehyde oxime With N-chloro-succinimide in chloroform
T=20°C; 0.333333 h;
2: polystyrene-supported vinyl selenide With triethylamine in dichloromethane
T=20°C; 12 h;
3: With dihydrogen peroxide in tetrahydrofuran
T=20°C; 0.5 h; Further stages.;
参考文献
Sheng, Shou-Ri; Xin, Qin; Liu, Xiao-Ling; Sun, Wu-Kang; Guo, Rui; Huang, Xian
Synthesis, 2006 , # 14 p. 2293 - 2296
反应条件
1.1: N-chlorosuccinimide / CHCl3 / 0.33 h / 20 °C
2.1: Et3N / CHCl3 / 12 h / 20 °C
2.2: aq. H2O2 / CHCl3 / 0.33 h / 20 °C
View Scheme
参考文献
Sheng, Shou-Ri; Liu, Xiao-Ling; Xu, Qu; Song, Cai-Sheng
Synthesis, 2003 , # 18 p. 2763 - 2764
反应条件
1.1: hydrogenchloride / N,N-dimethyl-formamide
1.2: 1 h / 20 °C
2.1: sodium / methanol / 4 h / 20 °C
3.1: sodium hydroxide / ethanol; water / 1 h / |Reflux
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C
2: triethylamine / ethanol; N,N-dimethyl-formamide / 16 h / 20 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
反应条件
1.1: hydrogenchloride / N,N-dimethyl-formamide
1.2: 1 h / 20 °C
2.1: sodium / methanol / 4 h / 20 °C
3.1: sodium hydroxide / ethanol; water / 1 h / |Reflux
4.1: triethylamine / tetrahydrofuran / -10 - -5 °C
4.2: -10 - 20 °C
View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DOTT, Pascal; HANLON, Steven Paul; HILDBRAND, Stefan; IDING, Hans; THOMAS, Andrew; WALDMEIER, Pius
Patent: WO2013/57123 A1, 2013 ;
反应条件
1: 3-chloro-benzaldehyde oxime With trifluorormethanesulfonic acid; silica gel in toluene
T=50°C; 0.5 h;
2: phenylacetylene in toluene
T=70°C; 3.5 h;
3: With CuCl2·2H2O; lithium chloride monohydrate; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane; propan-1-ol; toluene
T=60°C; P=9750.98 Torr; 4 h;
参考文献
Yuan, Shizhen; Li, Zhen; Xu, Ling
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 6 p. 1405 - 1409
