3-甲基-1H-吲哚-1,3-二羧酸-1-叔丁酯合成路线 （共 9 条）
反应条件
1: 1H-indole-3-carboxylic acid methyl ester With sodium hydride in tetrahydrofuran 0.5 h; Cooling in ice; 2: di-tert-butyl dicarbonate in tetrahydrofuran
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/103552 A1, 2009 ;
Location in patent: Page/Page column 31 ;
反应条件
palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=100°C; P=11251.1 Torr; continuous flow reactor;
参考文献
Koos, Peter; Gross, Ulrike; Polyzos, Anastasios; O'Brien, Matthew; Baxendale, Ian; Ley, Steven V.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 20 p. 6903 - 6908
反应条件
in benzene-d6 UV-irradiation;
参考文献
Feldman, Ken S.; Vidulova, Daniela Boneva
Heterocycles, 2003 , vol. 60, # 7 p. 1615 - 1623
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-40°C; Claisen condensation; 0.333333 h; Inert atmosphere;
参考文献
Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197
反应条件
hydrogen in dichloromethane T=20°C; 24 h; Inert atmosphere;
参考文献
Baeza, Alejandro; Pfaltz, Andreas
Chemistry - A European Journal, 2010 , vol. 16, # 7 p. 2036 - 2039
反应条件
lithium hexamethyldisilazane in tetrahydrofuran T=-40°C; Claisen condensation; 0.333333 h; Inert atmosphere;
参考文献
Venkat Ragavan; Vijayakumar; Rajesh; Palakshi Reddy; Karthikeyan; Suchetha Kumari
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4193 - 4197
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene T=0°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1559422 A1, 2005 ;
Location in patent: Page/Page column 130 ;
EP 1559422 A1
反应条件
hydrogen; 5-palladium/activated carbon in methanol; ethyl acetate
P=3102.97 Torr; 72 h;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/103552 A1, 2009 ;
Location in patent: Page/Page column 31 ;
反应条件
1: magnesium / methanol; dichloromethane / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
View Scheme
参考文献
Pietruszka, Joerg; Simon, Robert Christian
Chemistry - A European Journal, 2010 , vol. 16, # 48 p. 14534 - 14544
