2,2,3,3,3-五氟-1,1-二苯基-1-丙醇合成路线 （共 13 条）
反应条件
1: With tetramethyl-ammonium fluoride in ethylene glycol dimethyl ether T=-30 - 20°C; 2: With hydrogenchloride in ethylene glycol dimethyl ether T=20°C;
参考文献
Ignat'ev; Willner; Sartori
Journal of Fluorine Chemistry, 2009 , vol. 130, # 12 p. 1183 - 1191
反应条件
1: With tetramethyl-ammonium fluoride in 1,2-domethoxyethane T=-30 - 20°C; 2: With hydrogenchloride in water Acidic aqueous solutionAcidic conditions;
参考文献
MERCK PATENT GMBH
Patent: WO2005/105815 A1, 2005 ;
Location in patent: Page/Page column 36-37 ;
反应条件
tetrakis(dimethylamino)ethylene in N,N-dimethyl-formamide Irradiationcooling;
参考文献
Pooput, Chaya; Dolbier Jr., William R.; Medebielle, Maurice
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3564 - 3568
参考文献
Kaluszyner et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 4164,4167
参考文献
McGrath; Levine
Journal of the American Chemical Society, 1955 , vol. 77, p. 3656
反应条件
in octane; diethyl ether 0.166667 h; Ambient temperatureester added to C6H5Li; Title compound not separated from byproducts;
参考文献
Chen, Loomis S.; Chen, Grace. J.; Tamborski, Christ
Journal of Fluorine Chemistry, 1981 , vol. 18, p. 117 - 130
反应条件
1: tris(pentafluoroethyl)phosphine oxide With phenyl-magnesium bromide in tetrahydrofuran T=-60 - -45°C; 1 h; 2: benzophenone in tetrahydrofuran T=20°C; 2 h; 3: With hydrogenchloride; water Product distribution / selectivity;
参考文献
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
Patent: JP2005/522496 A, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
in octane; diethyl ether C6H5Li added to ester; 1.) -40 deg C, 10 min; 2.) r.t., 6 d;
参考文献
Chen, Loomis S.; Chen, Grace. J.; Tamborski, Christ
Journal of Fluorine Chemistry, 1981 , vol. 18, p. 117 - 130
反应条件
1: n-butyllithium; 1-iodo-pentafluoro-ethane in tetrahydrofuran; dichloromethane T=-61°C; 0.0666667 h; 2: benzophenone in tetrahydrofuran; dichloromethane T=-10°C; 1 h;
参考文献
Schwalbe, Thomas; Autze, Volker; Hohmann, Michael; Stirner, Wolfgang
Organic Process Research and Development, 2004 , vol. 8, # 3 p. 440 - 454
反应条件
in diethyl ether 1.) -78 deg C, 10 min; 2.) 0 deg C, 4 h; Further byproducts given;
参考文献
Chen, Loomis S.; Tamborski, Christ
Journal of Fluorine Chemistry, 1982 , vol. 20, p. 341 - 348
