1,4-二(2-甲基苯基)哌嗪合成路线 （共 7 条）
反应条件
1: piperazine With [2,2']bipyridinyl; 1,1-dimethylpropan-1-ol; nickel diacetate in tetrahydrofuran T=63°C; complex formation; 2 h; 2: ortho-chlorotoluene With styrene in tetrahydrofuran Arylation; 12 h; Heating;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
sodium t-butanolate; [Pd2(dba)2]; tri-tert-butyl phosphine in o-xylene T=120°C; Yield given. Yields of byproduct given;
参考文献
Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki
Tetrahedron Letters, 1998 , vol. 39, # 7 p. 617 - 620
参考文献
Dains et al.
Journal of the American Chemical Society, 1922 , vol. 44, p. 2640
Journal of the American Chemical Society, 1925 , vol. 47, p. 1985,1989
反应条件
aluminium silicate-catalyst; nitrogen T=240°C;
参考文献
Jur'ew; Gorin
Zhurnal Obshchei Khimii, 1954 , vol. 24, p. 1444,1446; engl. Ausg. S. 1429, 1430
参考文献
Kwok, Chun-Kiu; Mak, Thomas C. W.
Canadian Journal of Chemistry, 1988 , vol. 66, p. 1836 - 1847
参考文献
Bischoff; Nastvogel
Chemische Berichte, 1890 , vol. 23, p. 2026
Full Text Show Details
Bischoff; Hausdoerfer
Chemische Berichte, 1890 , vol. 23, p. 1998
Chemische Berichte, 1892 , vol. 25, p. 2284,2287
参考文献
Dains et al.
Journal of the American Chemical Society, 1922 , vol. 44, p. 2640
Journal of the American Chemical Society, 1925 , vol. 47, p. 1985,1989
