1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; acetic acid in water 3 h; Heating / reflux; 2: With hydrogenchloride in water; acetic acid 0.166667 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/60889 A1, 2004 ;
Location in patent: Page 20 ;